Branched-chain amino acid supplements will improved frailty index in patients with all stage of cirrhosis. Branched-chain amino acid supplement , liver frailty index
Conditions
Interventions
Diet control and branch chain amino acid supplement with exercises at least 30 minutes per day for 4 months.,Diet control and exercises at least 30 minutes per day for 4 months.
Active Comparator Dietary Supplement,Placebo Comparator Behavioral
BRCA,No BRCA
Sponsors
Thammasat University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Adults who diagnosed cirrhosis 2.Liver frailty index more than 4.5
Exclusion criteria
Exclusion criteria: 1.Patitents who recieved branch chain amino acid in 1 year 2.Patients was diagnosed hepatic encephalopathy more than stage 2 3.Patients was diagnosed hepatocellular carcinoma 4.Patients was diagnosed malignancy or severe comorbidity which survival less than 6months Exp congestive heart failure , COPD , ESRD 5.Pregnancy and breast feeding 6.Patients was post organ transplant 7.Patients was admit in hospital within 1 month 8.Patients was poor diabetic control (HbA1c more than 8.5)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frailty 4 months Liver frailty index | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function 4 months Liver function test,Mayo end stage liver disease score 4 months MELD score,Child pugh score 4 months CTP score,Renal 4 months Creatinine clearance ,Renal function 4months Electrolyte | — |
Countries
Thailand
Contacts
Public ContactNisakorn Limthanetkul
Thammasat university hospital
Outcome results
None listed