Effect of Low-Load Blood Flow Restriction Training for Subjects with Knee Osteoarthritis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210927002

Enrollment

Registered

2021-09-27

Start date

2021-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis Osteoarthritis

Interventions

Frequency: twice a week, total 12 weeks Intensity: 30% 1-RM, 30, 15, 15,15 repetition with 30 seconds rest periods Type: resistance training (Ex: squat, lunge, side-lying hip abduction, sitting knee e

Experimental Procedure/Surgery,Active Comparator Procedure/Surgery

Low load blood flow restriction training ,low load training

Eligibility

Sex/Gender

All

Age

50 Years to 85 Years

Inclusion criteria

Inclusion criteria: Meet 3 of the following 1. 50-85 years of age 2. Less than 30 minutes of morning stiffness on knee joint 3. Knee joint crepitus on active motion 4. Bony tenderness around knee joint 5. Bony enlargement around knee joint 6. No palpable warmth of synovium in knee joint

Exclusion criteria

Exclusion criteria: 1. Knee pain intensity less than 1 or greater than 8 (total 10 points) 2. Knee flexion range of motion less than 120 degree 3. Hip flexion range of motion less than 90 degree 4. History of trauma in past 3 months 5. Walk with assistive device 6. Resting systolic blood pressure lower than 100 mmHg or higher than 160 mmHg 7. Resting diastolic blood pressure higher than 100 mmHg 8. Peripheral vascular disease

Design outcomes

Primary

Measure	Time frame
Pain intensity every 4 weeks until end of the intervention Numerical Rating Scale	—

Secondary

Measure	Time frame
Isometric muscle strength (knee extension, knee flexion, hip extension, hip abduction) every 4 weeks until end of the intervention Hand-held dynamometer,Functional performance every 4 weeks until end of the intervention 30 second chair stand test, 4*10m fast-paced walk test, 20 seconds stair climbing test ,Disability every 4 weeks until end of the intervention Knee injury and Osteoarthritis Outcome Score (Chinese version),Rectus femoris muscle thickness every 4 weeks until end of the intervention Rehabilitative ultrasound imaging ,Self-report outcome measure of function every 4 weeks until end of the intervention Patient Specific Functional Scale,Maximal dynamic strength every 4 weeks until end of the intervention Submaximal predicted 1-RM with dumbbel,Rectus femoris msucle echo intensity every 4 weeks until end of the intervention Rehabilitative ultrasound imaging	—

Measure

Time frame

Isometric muscle strength (knee extension, knee flexion, hip extension, hip abduction) every 4 weeks until end of the intervention Hand-held dynamometer,Functional performance every 4 weeks until end of the intervention 30 second chair stand test, 4*10m fast-paced walk test, 20 seconds stair climbing test ,Disability every 4 weeks until end of the intervention Knee injury and Osteoarthritis Outcome Score (Chinese version),Rectus femoris muscle thickness every 4 weeks until end of the intervention Rehabilitative ultrasound imaging ,Self-report outcome measure of function every 4 weeks until end of the intervention Patient Specific Functional Scale,Maximal dynamic strength every 4 weeks until end of the intervention Submaximal predicted 1-RM with dumbbel,Rectus femoris msucle echo intensity every 4 weeks until end of the intervention Rehabilitative ultrasound imaging

—

Countries

Taiwan

Contacts

Public ContactChi Yuan Huang

National Yang Ming Chiao Tung University

jimmy0725@gmail.com886979194693

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026