Comparison of Time to Orientation between Combining Propofol with Sevoflurane and Sevoflurane in Patients undergoing Endoscopic Transnasal Surgery

Comparison of Time to Orientation between Combining Propofol with Sevoflurane and Sevoflurane in Patients undergoing Endoscopic Transnasal Surgery: a randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210924006

Enrollment

Registered

2021-09-24

Start date

2021-09-23

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pituitary tumor sinusitis propofol sevoflurane coadministration transsphenoidal surgery postoperative nausea and vomiting (PONV) endoscopic sinus surgery functional endoscopic sinus surgery (FESS)

Interventions

Anesthesia will be maintained with combined propofol intravenous infusion and sevoflurane (end-tidal concentration approximately 0.5 MAC) and target BIS value between 40-60 ,Anesthesia will be mainta

Active Comparator Drug,Active Comparator Drug

Combination of sevoflurane and propofol,Sevoflurane

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-60 years old 2. ASA physical status I-III 3. BMI 18-35 kg/m2

Exclusion criteria

Exclusion criteria: 1. Emergency surgery/unstable hemodynamics 2. Pregnancy 3. End stage renal disease or cirrhosis 4. Cognitive impairment 5. History of uncontrolled hypertension 6. Heart block greater than first degree 7. Obstructive sleep apnea 8. Chronic use of pain control 9. Allergy to the drugs used in the study

Design outcomes

Primary

Measure	Time frame
Time to orientation emergence of anesthesia timer, clock	—

Secondary

Measure	Time frame
Time from reversal to spontaneous ventilation, eye opening responded to sound and extubation emergence of anesthesia timer, clock,Incidence of serious coughing emergence of anesthesia observation,agitation emergence of anesthesia Ricker sedation-agitation scale,Pain score postanesthetic care unit numerical rating scale (NRS) ,Hemodynamics base line, intraoperative Mean arterial pressure, heart rate,Incidence of nausea and vomiting postanesthetic care unit 0 none, 1 mild, 2 severe nausea requiring antiemetics, 3 retching, vomiting or both	—

Measure

Time frame

Time from reversal to spontaneous ventilation, eye opening responded to sound and extubation emergence of anesthesia timer, clock,Incidence of serious coughing emergence of anesthesia observation,agitation emergence of anesthesia Ricker sedation-agitation scale,Pain score postanesthetic care unit numerical rating scale (NRS) ,Hemodynamics base line, intraoperative Mean arterial pressure, heart rate,Incidence of nausea and vomiting postanesthetic care unit 0 none, 1 mild, 2 severe nausea requiring antiemetics, 3 retching, vomiting or both

—

Countries

Thailand

Contacts

Public ContactWaroonkarn Mahavisessin

Khon Kaen University

waroma@kku.ac.th043348390

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026