Liver failure Acute liver failure Acute on chronic liver failure Hepatic encephalopathy Coagulopathy Hyperbilirubinemia Hyperammonia Uremia Liver failure Acute liver failure Acute on chronic liver failure Artificial liver support Extracorporeal liver support devices Plasma exchange Double plasma molecular adsorption system
Conditions
Interventions
Liver failure cases that admitted to ICU during the study period of time and did not receive artificial liver support treatments.,Liver failure cases that admitted to ICU during the study period of ti
double plasma molecular adsorption system,
hemoperfusion,
Treatment,Treatment
Supportive medical treatment ,Artificial liver support
Sponsors
Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age > 18 years 2. Admitted to ICU 3. Diagnosed with liver failure as 3.1 Acute liver failure (ALF) as EASL 20171 and determined using King s College criteria or 3.2 Acute on chronic liver failure (ACLF) as APASL 20195 with MELD score at least 30 or AARC score higher or equal to 8
Exclusion criteria
Exclusion criteria: 1. Poor prognostic coexisting disease (e.g. advanced malignancy) 2. Uncontrolled bleeding or infections 3. Uncontrolled hemodynamics instability 4. HIV infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day survival 28 days categorical data | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day survival 90 days categorical data,Length of ICU stay until discharge from ICU continuous data,Bilirubin clearance rate until discharge from ICU or 7 days continuous data,Liver transplantation rate (in admission) until hospital discharge continuous data,Renal replacement therapy rate until discharge from ICU continuous data,Adverse events until discharge from ICU categorical data | — |
Countries
Thailand
Contacts
Public ContactRanistha Ratanarat
Division of Critical Care, Department of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed