Comparison of Ventilator Associated Pneumonia between oral care with normal saline Solution and Chlorhexidine in a medical intensive care unit

Comparison of Ventilator Associated Pneumonia between oral care with normal saline Solution and Chlorhexidine in a medical intensive care unit: The VAP/ORC-CHX/NSS trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210920007

Enrollment

152

Registered

2021-09-20

Start date

2021-10-31

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

currently, Controversy of effective Oral care with chlorhexidine and 0.9% Normal Saline Solution for prevention VAP Ventilator Associated Pneumonia ,VAP ,Oral care ,Chlorhexidine ,0.9% NSS

Interventions

Oral care with Chlorhexidine with Standard Care and VAP bundle care,Oral Care with 0.9% Normal Saline Solution with Standard Care and VAP bundle care

Experimental Other,Placebo Comparator Other

Chlorhexidine,0.9% Normal Saline Solution

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. patient who received Ventilator > 2 day 2. > 18 year old 3. neutrophil > 3,600 cell/mm3 4. Platelet> 50,000 cell/mm3

Exclusion criteria

Exclusion criteria: 1. Chlorhexidine anaphylaxis and/or Mucositis 2. Re-intubation with in 24 hour 3. Readmission ICU and Last Reseach 4. Patient Surgery

Design outcomes

Primary

Measure	Time frame
Ventilator Associated Pneumonia Rate 48 hour VAP critiria	—

Secondary

Measure	Time frame
Mucositis Mouth Irritation BOE examination	—

Countries

Thailand

Contacts

Public ContactNipaporn Chantopas

Chulalongkorn Hospital

nipaporn.trc@gmail.com0863453507

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026