December 2019, an outbreak of pneumonia caused by a novel coronavirus occurred in China. As of 18-May-2021, a total of 162.7 million cases COVID-19 cases with 434,796 and 3.3 million deaths have been reported globally. This pandemic disease is caused by a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 causes diseases ranging from common cold to severe disease. The common signs and symptoms of infection include fever, URI symptom as cough, runny
Conditions
Interventions
The ethanolic extract of A. paniculata containing 20 mg of andrographolide in each capsule
Experimental Drug
Andrographis paniculata extract
Sponsors
Thai Traditional Medicine Knowlegde funding
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) age 18 to 60 years 2) diagnosis of SARS-CoV-2 infection by positive rRT-PCR test 3) being admitted to hospital within 72 hours of illness 4) presence of any signs and symptoms of mild COVID-19 (e.g., fever, cough, sore throat, malaise, headache, and diarrhea) 5) not having signs and symptoms of pneumonia or abnormal chest imaging
Exclusion criteria
Exclusion criteria: 1) Patient who be treated with any antiviral drugs i.e. favipiravir, remdesivir, Lopinavir, ritonavir, interferon (b1a), chloroquine or hydroxychloroquine 2) History of allergy to A. paniculata 3) Pregnancy or during lactation 4) Patient who has underlying medical conditions that increase risk of severe COVID-19 5) Patient with history of rheumatic heart disease and/or renal dysfunction due to Streptococcus group A 6) Patient who be treated with anticoagulants i.e., clopidogrel, warfarin, and aspirin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| symptom severity 5 days visual anolog scale,Adverse event 5 days number and severity of event | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflamatory cytokines 5 days Bio-plex assay,metabolite profile 5 days LC-MS,viral load 5 days rt-pcr ct value calculation | — |
Countries
Thailand
Contacts
Public ContactKulthanit Wanaratana
Department of Thai Traditional and Alternative Medicines, Thai Ministry of Public Health
Outcome results
None listed