Efficacy of Blood Flow Restriction with Low-Load Resistance exercise in adults who have risk of symptomatic knee osteoarthritis. (Double-blind randomized controlled trial)

Status

Unknown

Phases

Phase 1

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210903007

Enrollment

Registered

2021-09-03

Start date

2021-09-01

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A four-week, low-load resistance-training program with concurrent application of Blood flow restriction to the exercising limbs to improve knee extensor strength in Adults with risk factors for symptomatic Knee Osteoarthritis. Strengthening exercise, Blood flow restriction, knee osteoarthritis

Interventions

Resistance training with blood flow restriction to the exercising muscle may offer older adults, and particularly those with or at elevated risk for knee Osteoarthritis, while avoiding deleterious jo

Experimental Device

Blood Flow Restriction Exercise

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Age 40 years old or older 2.at least one of the following risk factors for symptomatic knee Osteoarthritis 2.1 BMI 25 kg/m2 or more 2.2 history of a knee joint injury or surgery 2.3 knee symptoms (pain, aching, or stiffness) 2.4 radiographic knee OA grade 0-1 of Kellgren and Lawrence classification system 3.No contraindication to exercise(AACVPR guideline)

Exclusion criteria

Exclusion criteria: 1.regular physical exercise 2.bilateral knee replacements; lower limb surgery in the last six months 3.back, hip or knee problems that affect walking 4.inflammatory joint or muscle disease5.neurologic diagnoses 6.cancer 7.peripheral vascular disease 8.history of myocardial infarction or stroke 9.chest pain during exercise or at rest; or need for supplemental oxygen.

Design outcomes

Primary

Measure	Time frame
1 Repetition Maximum of Knee Extensor Torque at 4 weeks after end of the intervention 1 Repetition Maximum	—

Secondary

Measure	Time frame
1 Repetition Maximum of Leg Press at 4 weeks after end of the intervention 1 Repetition Maximum,30 seconds chair stand test at 4 weeks after end of the intervention times/30 seconds,KOOS score at 4 weeks after end of the intervention Patient reported outcome using a questionnaire interview	—

Countries

Thailand

Contacts

Public ContactDr.Sakolawat Jaroenpakdee

Department of Rehabilitation Medicine, Maharat Nakhon Ratchasima Hospital

sakolawat.jp@cpird.in.th0991237588

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026