A comparison of clinical outcome among undenatured collagen type II, Glucosamine sulphate and Diacerein on osteoarthritic knee treatment :A randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210901003

Enrollment

216

Registered

2021-09-01

Start date

2021-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This research is designed to fulfill the understanding of the clinical outcome of osteoarthritic knee treatment by Undenatured collagen type II, Glucosamine sulphate and Diacerein. osteoarthritic knee, undenatured collagen type II, Glucosamine sulphate ,Diacerein, WOMAC scores

Interventions

Undenatured collagen type II 40 mg (Lonza, USA) 1 capsule after breakfast, Placebo for after lunch and dinner,Glucosamine sulphate(Viatryl-s) 500mg (Rottapharm, Ireland) 1 capsule after breakfast,

Experimental Drug,Experimental Drug,Experimental Drug,Experimental Drug

Undenatured collagen type II,Glucosamine sulphate,Diacerein,Placebo

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: -Primary knee OA based on the clinical criteria of the American College of Rheumatology -Had radiographic evidence of OA with a Kellgren and Lawrance grade of 2-3 -Had not received UC-II or pCGS or diacerein within previous 6 months -Had pain score (NPRS) at knee more than 4

Exclusion criteria

Exclusion criteria: -Had undergone knee replacement surgery -Previous intra-articular treatment of the knee joint with any product(corticosteroids in the previous 2 months or hyaluronic acid in the previous 6months) -Gastrointestinal disease (gastroesophageal reflux disorder, inflammatory bowel syndrome, peptic ulcer, and duodenal ulcer) -Chronic kidney disease (GFR < 30) -Liver disease (Cirrhosis child B-C,Hepatic failure,HCC) -Uncontrolled diabetes mellitus (HbA1C < 7.0) -Allergy to Undenatured collagen type II, Glucosamine sulphate, Diacerein, Acetaminophen, Naproxen -Immobilization -Usage of warfarin -had difficulty with movement

Design outcomes

Primary

Measure	Time frame
WOMAC scores 0, 12, 24, 36 wks 220 points	—

Secondary

Measure	Time frame
Numeric pain rating scale 0, 12, 24, 36 wks counts the point,rescue medication 4, 12, 24, 36 wks times, dose of usage,joint space width 24, 36 wks measure in millimeters,complication 4, 12, 24, 36 wks record forms, and history taking,6 min walk test and Time to get up and go test 24, 36 wks meters and seconds	—

Countries

Thailand

Contacts

Public ContactCHATURONG PORNRATTANAMANEEWONG

Siriraj hospital

toonchaturong@gmail.com0817553977

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Sep 8, 2026