Helicobacter pylori infection High-dose PPI based triple therapy, Helicobacter pylori eradication, Lampang hospital
Conditions
Interventions
Standard dose PPI-based triple therapy (omeprazole 20 mg bid, amoxicillin 1000 mg bid, and clarithromycin 500 mg bid) for 14 days.,High dose PPI-based triple therapy (omeprazole 40 mg bid, amoxicillin
Standard dose PPI-based triple therapy group,High dose PPI-based triple therapy group
Sponsors
National Research Council of Thailand (NRCT)
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients age greater than or equal to 18 years old, 2. H. pylori infection, 3. Did not receive prior eradication therapy
Exclusion criteria
Exclusion criteria: 1. history of gastric cancer or gastrectomy, 2. severe concurrent disease or malignancy, 3. pregnant or lactating, 4. alcohol abuse or drug addiction, 5. previous allergic reaction to study drugs, 6. history of taking PPI, bismuth or antibiotics within 4 weeks, 7. subjects declined to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate of H. pylori infection 6 weeks after completion of therapy Urea breath test | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects of study drugs 6 weeks after completion of therapy Patients reported side effects using a questionnaire interview | — |
Countries
Thailand
Contacts
Public ContactTharadol Poolthawee
Ministry of health
Outcome results
None listed