Comparison of clinical outcomes between polyvalent and monovalent antivenoms: a pilot study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210826004

Enrollment

Registered

2021-08-26

Start date

2021-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Snakebite patients requiring antivenoms Snakebite Antivenom Polyvalent Monovalent The Thai Red Cross Society

Interventions

The patient receives polyvalent antivenoms for 1. Hematotoxic snake: Hemato polyvalent antivenom 3-5 vials + NSS 100 ml intravenous (IV) drip in 30-60 minutes or 2. Neurotoxic snake: Neuro polyvalent

s viper, green pit viper, or Malayan pit viper 3-5 vials + NSS 100 ml IV drip in 30-60 minutes 2. Neurotoxic snake: monovalent antivenom against cobra, king cobra, Malayan krait, or banded krait 10 vi

Experimental Drug,Active Comparator Drug

Polyvalent antivenom,Monovalent antivenom

Eligibility

Sex/Gender

All

Age

7 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients older than 7 years old who are bitten by snakes and present to King Chulalongkorn Memorial Hospital (KCMH) from 1 September 2021 to 31 August 2022 (or after IRB approval). 2. Antivenom therapy is indicated

Exclusion criteria

Exclusion criteria: 1. The patient is not registered in the KCMH database 2. The bite is confirmed to be from animals other than snakes 3. The patient does not consent to participate in the research 4. The patient is allergic to horse-derived products 5. The patient has a history of systemic corticosteroid use or receive medications that might interfere with the study (upon investigators consideration) 4 weeks before the bite

Design outcomes

Primary

Measure	Time frame
Efficacy - local effect at day 0, 1, 3, 7 after bite limb circumference,Efficacy - hematotoxic effect at day 0, 1, 3, 7 after bite INR, 20min WBCT, platelet, fibrinogen,Efficacy - neurotoxic effect at day 0, 1, 3, 7 after bite motor strength,Efficacy at day 7 after bite mortality	—

Secondary

Measure	Time frame
Side effect at 0, 30 min, 60 min, 2 h, after antivenom and day 7 after bite anaphylactic symptoms	—

Countries

Thailand

Contacts

Public ContactSuthimon Thumtecho

King Chulalongkorn Memorial Hospital

suthimont@gmail.com0922614163

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026