A patient who required general anesthesia for any kind of surgery General anesthesia Rapid sequence intubation
Conditions
Interventions
Using intravenous rocuronium 1.2 mg/kg in rapid sequence intubation,Using intravenous cisatracurium 0.4 mg/kg in rapid sequence intubation
Active Comparator Drug,Experimental Drug
Rocuronium,Cisatracurium
Sponsors
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. 18-65 years old adult patients who are willing to join the research, 2. Patients undergoing more than 1 hour of elective surgery requiring general anesthesia, 3. Patients who skipped heavy meals for more than 8 hours, light meals for more than 6 hours, and clear liquids for more than 2 hours before undergoing anesthesia, 4. Patients with American Society of Anesthesiologists Physical Status (ASA PS) classification I-III
Exclusion criteria
Exclusion criteria: 1. Patients refuse to participate in the research or request to withdraw, 2. Patients with a history of drug allergy related to the research, 3. Patients who are pregnant or breastfeeding, 4. Patients who are predicted difficult intubation, 5. Patients at high risk of aspiration, 6. Patients with a history of asthma or reactive airway disease were treated with medication at the time of the study, 7. Patients with severe diseases such as cardiovascular disease, neuromuscular disease, impaired hepatic and renal function, 8. Patients who have a cardiac pacemaker, 9. Patients with a history of using medication that affect the action of muscle relaxants such as aminoglycoside, antidepressants, anticonvulsants, antiarrhythmic (calcium channel blockers or quinidine), and magnesium sulfate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intubating condition 90 seconds after neuromuscular blocking agent administration Intubating condition scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesiologist satisfraction After successful intubation Numeric rating scale,Train of four at 90 sec 90 seconds after neuromuscular blocking agent administration Train of four monitoring,Train of four at successful intubation At successful intubation Train of four monitoring,Time to TOF 0 During general anesthesia Train of four monitoring,Time to TOF 1 During general anesthesia Train of four monitoring,Skin manifestation During general anesthesia Number of events,Hypotension During general anesthesia Number of events required treatment,Hypertension During general anesthesia Number of events required treatment,Tachycardia During general anesthesia Number of events required treatment,Bradycardia During general anesthesia Number of events required treatment | — |
Countries
Thailand
Contacts
Public ContactNapanont Kiatmongkolkul
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed