Impact of number of autotransplanted parathyroid fragment in total parathyroidectomy for secondary hyperparathyroidism: a prospective randomized trial

Impact of number of autotransplanted parathyroid fragment between 20 and 45 pieces in total parathyroidectomy for secondary hyperparathyroidism: a prospective randomized trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210821001

Enrollment

Registered

2021-08-21

Start date

2019-04-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic renal failure patients with hyperparathyroidism Renal failure Hyperparathyroidism Surgery

Interventions

Conventional autotransplantation of 20 parathyroid fragments,Experimental autotransplantation of 45 parathyroid fragments

Active Comparator Procedure/Surgery,Experimental Procedure/Surgery

20 parathyroid fragments implantation,45 parathyroid fragments implantation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients age 18-80 year Severe secondary hyperparathyroidism i.e. persistently elevated PTH values > 800 pg/ml for > 6 months, serum calcium >10.2 mg/dl, phosphorus > 5.5 mg/dl, presence of calciphylaxis, or erythropoietin-resistant anemia who fail to respond to medical therapy.

Exclusion criteria

Exclusion criteria: Previous thyroid or parathyroid surgery Previous neck irradiation Unable to identify at least 4 parathyroids.

Design outcomes

Primary

Measure	Time frame
parathyroid hormone level 1st, 3rd, 6th, 12th, and 18th month after surgery serum parathyroid hormone	—

Secondary

Measure	Time frame
reoperative rate 6th, 12th, and 18th month number of reoperation due to persist/recurrent hyperparathyroidism	—

Countries

Thailand

Contacts

Public ContactPichit Sittitrai

Department of Otolaryngology, Faculty of Medicine, Chiang Mai University

psittitrai@yahoo.com6653935562

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026