Sepsis and Septic Shock Patients Undergoing Surgery Ketamine, Etomidate, Sepsis, Septic shock, Hemodynamic
Conditions
Interventions
Induction with ketamine 1 mg/kg,Induction with etomidate 0.3 mg/kg
Active Comparator Drug,Active Comparator Drug
Ketamine ,Etomidate
Sponsors
Khon kaen University
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. 18-65 years of age 2. Undergoing general anesthesia with endotracheal intubation
Exclusion criteria
Exclusion criteria: 1. already intubation 2. have a contraindication for arterial canulation 3.contraindication for ketamine used such as increase ICP, increase IOP, myocardial infraction 4. contraindication for etomidate such as adrenal insufficiency 5.suspected difficult airway
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure (MAP) first 10 minutes after induction of anesthesia MAP measure by invasive blood pressure monitoring | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of post-induction hypotension first 10 minutes after induction of anesthesia MAP, Dose of norepinephrine,Heart rate first 10 minutes after induction of anesthesia Heart rate by ECG monitor,Amount of fluid resuscitation 30 minutes after induction of anesthesia ml of fluid,Urine output 30 minutes after induction of anesthesia ml of urine,Dose of vasopressor 10 minutes after induction of anesthesia Noreponephrine as mcg/kg/min,ABG value before induction and 30 minutes after induction of anesthesia Arterial blood sampling | — |
Countries
Thailand
Contacts
Public ContactSaranyoo Nonphiaraj
Faculty of Medicine, Khon Kaen University
Outcome results
None listed