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The comparison of efficacy between intrathecal morphine combined with either selective COX-II inhibitor or acetaminophen and intrathecal morphine alone for analgesia after cesarean section: a randomized control trial

The comparison of efficacy between intrathecal morphine combined with either selective COX-II inhibitor or acetaminophen and intrathecal morphine alone for analgesia after cesarean section: a randomized control trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210813001
Enrollment
177
Registered
2021-08-13
Start date
2020-10-23
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Opioid consumption, quality of pain control, complication and satisfaction in postoperative period of elective cesarean section Intrathecal morphine, Acetaminophen, COX-II inhibitor, Non-steroidal anti-inflammatory drugs, NSAIDs, Cesarean section

Interventions

Paracetamol 1000 mg IV at recovery room then 1000 mg IV or oral q6h x 1 day,Parecoxib 40 mg IV at recovery room then 40 mg IV q12h x 1 day
Active Comparator Drug,Active Comparator Drug
Paracetamol group,Parecoxib group

Sponsors

None listed

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Female participant age 18-40 years old undergoing elective cesarean section 2. ASA II 3. BMI 18-40 kg/m2

Exclusion criteria

Exclusion criteria: 1. Patient deny 2. Unable to communicate with researcher 3. Medication allergy or contraindication to medication which will be administered in this study 4. Contraindication of spinal anesthesia 5. Chronic opioid user

Design outcomes

Primary

MeasureTime frame
Opioid consumption 24 hours postoperative Collection from PCA machine

Secondary

MeasureTime frame
Time to first dose opioid rescue Time to first dose opioid rescue Collection from PCA machine,Pain score (NRS) 1,4,8,12,24 hours postoperative Questionaire,Rate of complication 24 hours postoperative Questionaire,Satisfaction score 24 hours postoperative Questionaire

Countries

Thailand

Contacts

Public ContactDissakul Prasitreungsuk

King Chulalongkorn Memorial Hospital

tum.sg89@gmail.com0625151655

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026