Trigeminal neuralgia (TN) is a rare neuropahic condition with symptoms as brief, abrupt onset electric shock-like pain in the area of trigeminal nerve innervation. Trigeminal neuralgia Neuropathic pain
Conditions
Interventions
Placebo for control group,Lacosamide 200 mg/day ,Lacosamide 400 mg/day
Control group,Low dose group,High dose group
Sponsors
Neurosciences Research and Development Group, Khonkaen University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult 2. Diagnosed as trigeminal neuralgia according to International Classification of Headache Disorder 3rd edition (ICHD-3) 3. Numeric rating scale of pain higher than 4 4. Never received any treatment or have not taken any drugs in last 4 weeks 5. Physical condition is categorized as American Society of Anesthesiologist (ASA classification) 1 or 2 6. Can communicate in Thai
Exclusion criteria
Exclusion criteria: 1. History of microvascular decompression surgery without recurred symptom 2. Impaired physical condition or psychological problems 3. Pregnancy and lactation 4. History of suicide commitment 5. Impaired liver or kidney functions 6. History of experimental drug allergy 7. Unwilling to join the sudy 8. Could not come to follow up regularly
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity Baseline, 2weeks, 4 weeks and 8 weeks after numeric rating scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical function Baseline, 2weeks, 4 weeks and 8 weeks after BPI-facial questionnaire,Emotional function Baseline, 2weeks, 4 weeks and 8 weeks after Thai Hospital anxiety and depression scales questionnaire,Adverse effects Baseline, 2weeks, 4 weeks and 8 weeks after Blood investigation (complete blood count, liver function test, creatinine, electrolytes),Pain quality Baseline, 2weeks, 4 weeks and 8 weeks after Neuropathic Pain Symptoms Inventory (NPSI) | — |
Countries
Thailand
Contacts
Public ContactTeekayu Jorns
Khonkaen University
Outcome results
None listed