Effects of vitamin D2 supplementation on semen quality in vitamin D-insufficient infertile men: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210804004

Enrollment

Registered

2021-08-04

Start date

2022-01-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitamin D insuffiency infertile men vitamin D supplementation semen quality vitamin D insufficiency infertile men

Interventions

weekly 60000 IU of vitamin D2 supplementation for 12 weeks,weekly placebo for 12 weeks

Experimental Drug,Placebo Comparator Drug

vitamin D supplementation,placebo

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: infertile men with abnormal semen quality serum vitamin D level less than 30 ng/ml

Exclusion criteria

Exclusion criteria: history of allergy or having contraindication to vitamin D supplementation history of vitamin D supplementation within 12 weeks history of genital and groin surgery inflammation around genitalia and varicocele urinary tract infection disease of calcium, phosphorus and bone metabolism severe renal or liver disease

Design outcomes

Primary

Measure	Time frame
semen quality 12 weeks computer-aided sperm analysis	—

Secondary

Measure	Time frame
prevalence of vitamin D insuffiency among infertile men 1 year prevalence	—

Countries

Thailand

Contacts

Public ContactCharn Watanasomsiri

Faculty of Medicine, Prince of Songkla University

charn_art1@hotmail.com0896649181

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026