clinical pain severity in chronic knee osteoarthritis. Transcranial direct current stimulation, Chronic knee osteoarthritis, Dorsolateral prefrontal cortex, Pain
Conditions
Interventions
Participants will receive 20 min of tDCS before exercise by qualified physiotherapist. The program was generated for 3 times per week for 4 weeks (12 sessions). Moreover, all participants will be taug
Active tDCS plus exercise,Sham tDCS plus exercise
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age 50 - 90 years old 2. Diagnosed chronic knee osteoarthritis by American College of Rheumatology present with knee joint pain plus at least 3 of following 2.1 Age more than 50 yr 2.2 Morning stiffness more than 30 mins 2.3 Crepitus 2.4 Bony enlargement 2.5 Bony tenderness 2.6 No palpable warmth 3. Clinical knee pain by VAS 40-70 mm 4. Kellgren and Lawrence classification system grading 1 - 3 5. Knee pain at least 3 mo. 6. Can sit with support more than 20 mins 7. Not participate in others trial 8. Willing to participate by themselves
Exclusion criteria
Exclusion criteria: 1. Hemodynamic or Neurological condition not stable 2. Cannot communicate or follow command 3. Acute inflammation on studied side 4. Knee joint replacement on studied side 5. History of intraarticular injection at studied side: steroid within 3 months and hyaluronic acid within 6 month 6. Have to had pain killer such as NSIADs within 2 weeks 7. History of MDD 8. History of non-invasive brain stimulation such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS) 9. Contraindications to tDCS 9.1 Skin pathology, infection, wound, vasculitis at stimulate site 9.2 History of bleeding tendency 9.3 History of seizure or in family 9.4 History of migraine 9.5 History of brain surgery 9.6 History of traumatic brain injury which alteration of conscious more than 15 min 9.7 Neurodeficit 9.8 Implanted metal device: pacemaker, metal plate, wires 9.9 Pregnancy 9.10 History adverse effect from other brain stimulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pain severity Before and after intervention, past 4 wk after intervention Visual analogue scale (mm) | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical function Before and after intervention, past 4 wk after intervention WOMAC score (questionaire),Pressure pain threshold Before and after intervention, past 4 wk after intervention digital algometer (kPa)),Quality of life Before and after intervention, past 4 wk after intervention The Short Form Health Survey-36 questionaire | — |
Countries
Thailand
Contacts
Public ContactKanlayanee Boonprasit
Resident
Outcome results
None listed