abdominal fatness abdominal obesity metabolic syndrome hypertension prediabetes dyslipidemia aged black garlic hypertension prediabetes dyslipidemia metabolic syndrome
Conditions
Interventions
Subjects will receive 8-9 hard capsules containing placebo,Subjects will receive 8-9 hard capsules containing aged black garlic containing S-allylcysteine (SAC) 1.1mg/day,Subjects will receive 8-9 har
placebo, aged black garlic containing S-allylcysteine (SAC) 1.1mg/day, aged black garlic containing S-allylcysteine (SAC) 2.2mg/day
Sponsors
Agricultural Research Development Agency (ARDA)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-60 years old 2. no prior history of allergy to garlic 3. body mass index 25-35 kg/m2 4. waist circumference >80 and >90 cm in women and men, respectively 5. blood pressure >130/85 mmHg or taking anti-hypertensive medications
Exclusion criteria
Exclusion criteria: 1. allergy to garlic 2. has taken dietary supplements containing garlic within 1 month of enrollment 3. use of anticoagulants within 3 months of enrollment 4. body weight change of 5kg or more within 6 weeks of enrollment 5. blood pressure 180/110 mmHg or higher 6. fasting plasma glucose 300 mg/dL or higher or HbA1c 10% or higher 7. history of type 1 diabetes 8. history of type 2 diabetes which requires medications (those treated with lifestyle intervention only can be enrolled into the study) 9. receiving steroids antibiotics or probiotics within 3 months of enrollment 10. pregnancy and lactation 11. gastrointestinal diseases affecting digestion and absorption, including but not limited to short bowel syndrome, inflammatory bowel diseases, chronic pancreatitis, and prior bariatric surgery 12. uncontrolled cardiovascular diseases, uncontrolled psychiatric disorder, terminal illness 4. bleeding disorder or chronic liver disease 5. current smoking 6. alcohol use of more than 2 standard drinks/day, >5days/week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure baseline, 2 weeks, and 12 weeks mmHg, body weight and waist circumference baseline, 2 weeks, and 12 weeks kg and cm | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory parameters baseline, 2 weeks, and 12 weeks CBC, BUN, Cr, AST, ALT, ALP, PT, aPTT, FPG, HbA1c, cholesterol, TG, HDLc, LDLc, CRP, gut microbiome analysis baseline, 2 weeks, and 12 weeks stool,proteomic analysis baseline, 2 weeks, and 12 weeks urine | — |
Countries
Thailand
Contacts
Public ContactChaniphun Butryee
Mahidol University
Outcome results
None listed