healthy subjects aged black garlic toxicology
Conditions
Interventions
Subjects will receive 8-9 hard capsules containing placebo,Subjects will receive 8-9 hard capsules containing aged black garlic containing S-allylcysteine (SAC) 2.2mg/day
placebo,aged black garlic containing S-allylcysteine (SAC) 2.2mg/day
Sponsors
Agricultural Research Development Agency (ARDA)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-60 years old 2. BMI 18.5-22.9 kg/m2 3. waist circumference < 80 cm and < 90 cm for women and men, respectively 4. no prior medical problems 5. normal screening laboratory parameters including kidney function, liver function tests, complete blood count, coagulogram, glucose, and lipid levels 6. no antihypertensive medications and blood pressure <120/80 mmHg and >90mmHg 7. no prior history of garlic allergy 8. no dietary supplements containing garlic within 1 month of enrollment 9. no anticoagulants within 3 months of enrollment
Exclusion criteria
Exclusion criteria: 1. history of allergy to garlic 2. has taken dietary supplements containing garlic within 1 month of enrollment 3. pregnancy and lactation 4. bleeding disorder or chronic liver disease 5. current smoking 6. alcohol use of more than 2 standard drinks/day, >5days/week 7. use of anticoagulants 8. uncontrolled psychiatric disorder 9. terminal illness 10. blood pressure of 120/80 mmHg or higher, or <90mmHg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure baseline, 2 weeks, and 12 weeks mmHg,body weight and waist circumference baseline, 2 weeks, and 12 weeks kg and cm | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory parameters baseline, 2 weeks, and 12 weeks CBC, BUN, Cr, AST, ALT, ALP, PT, aPTT, FPG, HbA1c, cholesterol, TG, HDLc, LDLc, CRP,gut microbiome analysis baseline, 2 weeks, and 12 weeks stool | — |
Countries
Thailand
Contacts
Public ContactPornpoj Pramyothin
Mahidol University
Outcome results
None listed