diabetes prediabetes impaired fasting glucose obesity diabetes glycemic index postprandial glucose rice medical food
Conditions
Interventions
Subjects are asked to drink rice-based diabetes-specific medical food (liquid) which contains 25g of carbohydrates within 12-15 minutes. Blood is drawn at baseline and 15,30,45,60,90,120 minutes to me
Experimental Dietary Supplement,Experimental Dietary Supplement,Active Comparator Dietary Supplement,Active Comparator Dietary Supplement
rice-based diabetes-specific medical food (liquid),rice-based diabetes-specific medical food (powder),commercially-available medical food (non-diabetes),commercially-available diabetes-specific medic
Sponsors
Agricultural Research Development Agency (ARDA)
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-60 years old 2. body mass index between 25-35 kg/m2 3. diagnosed with diabetes within 6 years of enrollment OR diagnosed with prediabetes either by fasting plasma glucose >=126 mg/dL or HbA1c >=5.7% 3. diabetes is being treated by lifestyle therapy alone or in conjunction with oral glucose-lowering drugs
Exclusion criteria
Exclusion criteria: 1. receives insulin 2. prior history of gastroparesis 3. HbA1c >9% or diagnosed with diabetes >6 years prior to enrollment 4. blood pressure >= 180/110 mmHg or triglyceride levels >500 mg/dL 5. prior history of severe hyperglycemic or severe hypoglycemic episodes requiring hospitalization within 1 year of enrollment 6. severe medical problems requiring ongoing treatment, including but not limited to cancer, cardiac, pulmonary, hepatic, brain diseases or severe infections within 1 year of enrollment 7. history of surgery or hospitalization within 2 weeks of enrollment 8. history of allergy to medical foods (or its components) used in this study 9. body weight change of 5kg or more within 6 weeks of enrollment 10. pregnancy and lactation 11. prior history of bariatric surgery 12. diagnosis of diseases which significantly affect food digestion and absorption such as inflammatory bowel disease, Crohn's disease, ulcerative colitis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postprandial glucose area under the curve (AUC) 0-120min glucose AUC after each intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| postprandial insulin area under the curve (AUC) 0-120min insulin AUC after each intervention | — |
Countries
Thailand
Contacts
Public ContactPornpoj Pramyothin
Mahidol University
Outcome results
None listed