healthy volunteers postprandial glucose gut microbiome rice hyperglycemia glycemic index
Conditions
Interventions
Subjects are asked to drink 50g glucose solution (standard food) within 12-15 minutes. Blood is drawn at baseline and 15,30,45,60,90,120 minutes to measure changes in plasma glucose and insulin level
Placebo Comparator Dietary Supplement,Active Comparator Dietary Supplement,Active Comparator Dietary Supplement,Active Comparator Dietary Supplement,Active Comparator Dietary Supplement
glucose50g,Hommali rice,Riceberry rice,Sinlek Rice,3G rice
Sponsors
Agricultural Research Development Agency (ARDA)
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.age 18-60 years old 2. body mass index 18.5-23 kg/m2 3. does NOT meet any of following the diagnostic criteria for metabolic syndrome defined as 3.1 waist circumference of 90 or 80 cm or more for men and women, respectively 3.2 triglyceride level >= 150 mg/dL or receiving medications for high blood lipids 3.3 HDL level <40 mg/dL or <50 mg/dL for men and women, respectively 3.4 blood pressure >=130 mmHg systolic or >=85 mmHg diastolic 3.5 fasting plasma glucose >= 100mg/dL or receiving medications for treatment of hyperglycemia 4. NOT receiving medications for treatment of hyperglycemia, high blood pressure, or high blood lipid levels
Exclusion criteria
Exclusion criteria: 1. history of allergy to medical food (or one or more of its components) used in the current study 2. weight increase or decrease of 5kg or more within 6 weeks before enrollment 3. severe hypertension defined as blood pressure 180/110 mmHg or more or blood triglyceride levels of 500mg/dL or more 4. prior diagnosis of diabetes 5. receiving steroids or antibiotics within 6 weeks of enrollment 6. pregnancy or lactation 7. prior history of diseases affecting GI digestion or absorption such as inflammatory bowel disease, Crohn's disease, ulcerative colitis 8. prior history of bariatric surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postprandial glucose area under the curve (AUC) 0-120min glucose AUC after each intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Postprandial changes in plasma glucose, insulin, GLP-1, GIP, Ghrelin, PYY levels 0-120min AUC after each intervention | — |
Countries
Thailand
Contacts
Public ContactPornpoj Pramyothin
Mahidol University
Outcome results
None listed