Acute Ocular Complications in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Thailand Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Severe cutaneous adverse reaction SCAR Type IV hypersensitivity reaction Delayed T-cell-mediated type hypersensitivity reaction Drug-induced SJS and TEN Drug reaction Culprit drugs Ocular complication Severe ocular complications Ocular involvement Biomarkers Asian Southeast Asian
Conditions
Interventions
ocular severity score grade 0 - 2
,ocular severity score grade 3
Screening,Screening
Severe ocular complications,Severe ocular complications
Sponsors
Ratchadapisek Sompoch Endowment Fund
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients in Thai SCARs database (dermatological diagnosis of SJS or TEN or SJS-TEN overlap) with ocular involvement 2. The patients had medical records of the acute phase, which were fully accessible to evaluate prognostic factors 3. The patients did not have a history of other ocular surface disorder or ocular surgery
Exclusion criteria
Exclusion criteria: 1. Clinical information was insufficient to calculate the SCORTEN 2. Sepsis (in serum analysis) 3. Positive blood culture (in serum analysis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical factors of acute severe ocular complications in SJS/TEN patients Acute phase of SJS/TEN (with in 2 weeks after onset of SJS/TEN) Severity scores for TEN (SCORTEN), Grading score for acute ocular severity of SJS/TEN | — |
Secondary
| Measure | Time frame |
|---|---|
| Biological markers for acute severe ocular complications in SJS/TEN patients Serum from acute phase of SJS/TEN (with in 2 weeks after onset of SJS/TEN) samples were analyzed using a bead-based multiplex immunoassay | — |
Countries
Thailand
Contacts
Public ContactRawiphan Panpruk
Chulalongkorn University
Outcome results
None listed