The analgesic efficacy between the iPACK block and genicular nerve blocks when combined with continuous adductor canal block for postoperative analgesia and functional outcome after Total knee arthroplasty: A randomized control trial

The efficacy between local anesthetic injection into the interspace between the popliteal artery and posterior capsule of the knee (iPACK) block and genicular nerve block when combined with continuous adductor canal block for postoperative analgesia and functional outcome after Total knee arthroplasty: A randomized control trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210727001

Enrollment

132

Registered

2021-07-27

Start date

2021-09-06

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OA Knee going on total knee arthroplasty Knee arthroplasty Nerve block Postoperative pain Analgesia analgesia

Interventions

Ultrasound-guided local anesthetic injection into the interspace between the popliteal artery and posterior capsule of the knee (iPACK) is performed by injecting of 0.25% bupivacaine 20 ml combined wi

Experimental Procedure/Surgery,Experimental Procedure/Surgery,Experimental Procedure/Surgery

iPACK block group,Genicular nerve blocks group,iPACK block + Genicular nerve blocks group

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patient who was scheduled for total knee arthroplasty at King Chulalongkorn Memorial Hospital ASA class 1 to 3 ASA class 1 A normal healthy patient ASA class 2 A patient with mild systemic disease Mild diseases only without substantive functional limitations ASA class 3 A patient with severe systemic disease but not threaten to life Body mass index BMI between 18 to 40 kg/m2

Exclusion criteria

Exclusion criteria: 1. refuse to participate this study, 2. unable to cooperate or cognitive impairment, 3. allergy to any drug in this study, 4. contraindication to neuraxial anesthesia, 5. contraindication to NSAIDs Ketorolac and Celebrex, 6. chronic opioids use or diagnosed of neuropathic pain, 7. unable to performed Time up and go test

Design outcomes

Primary

Measure	Time frame
Postoperative pain score during movement 8 hours Visual Analog Scale	—

Secondary

Measure	Time frame
Postoperative pain score at rest and during movement preop,0,4,8,12,24,36,48 hours Visual Analog Scale,postoperative opioid consumption 12, 24, 48 hours Milligram of Morphine Consumption,Quadriceps Strength Postoperative 0, 1, 2, 3 Days Maximum voluntary isometric contraction,Degree of knee flexion (active and passive) Postoperative 0, 1, 2, 3 Days Degree of range of motion,Timed up and go test Postoperative 0, 1, 2, 3 Days Rehabilitation after surgery,Postoperative Complication Postoperative 0, 1, 2, 3 Days Postoperative Nausea Vomiting, Dizziness, Fall, Sleep disturbance,Length of stay Postoperative to discharge out of hospital Hours,Sensory and Motor Function of Tibial Nerve after spinal anesthesia wear off completely Plantar Flexion and Cold Sensation of Plantar aspect,Sensory and Motor Function of Common Peroneal Nerve after spinal anesthesia wear off completely Dorsiflexion and Cold Sensation at Dorsum aspect,Patient satisfaction Postoperative day 2 Satisfactory score (1-10),Postoperative posterior knee pain prep,0,4,8,12,24,36,48 hours Visual Analog scale,Area under the curve of postoperative pain scores 12 and 24 hours pain scores	—

Measure

Time frame

Postoperative pain score at rest and during movement preop,0,4,8,12,24,36,48 hours Visual Analog Scale,postoperative opioid consumption 12, 24, 48 hours Milligram of Morphine Consumption,Quadriceps Strength Postoperative 0, 1, 2, 3 Days Maximum voluntary isometric contraction,Degree of knee flexion (active and passive) Postoperative 0, 1, 2, 3 Days Degree of range of motion,Timed up and go test Postoperative 0, 1, 2, 3 Days Rehabilitation after surgery,Postoperative Complication Postoperative 0, 1, 2, 3 Days Postoperative Nausea Vomiting, Dizziness, Fall, Sleep disturbance,Length of stay Postoperative to discharge out of hospital Hours,Sensory and Motor Function of Tibial Nerve after spinal anesthesia wear off completely Plantar Flexion and Cold Sensation of Plantar aspect,Sensory and Motor Function of Common Peroneal Nerve after spinal anesthesia wear off completely Dorsiflexion and Cold Sensation at Dorsum aspect,Patient satisfaction Postoperative day 2 Satisfactory score (1-10),Postoperative posterior knee pain prep,0,4,8,12,24,36,48 hours Visual Analog scale,Area under the curve of postoperative pain scores 12 and 24 hours pain scores

—

Countries

Thailand

Contacts

Public ContactWirinaree Kampitak

King Chulalongkorn Memorial Hospital

nutong127@yahoo.com66899955666

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026