Does preoperative administration of Etoricoxib 120 mg have the higher efficacy in reduction of postoperative pain in mandibular third molar surgery compared to postoperative administration of the same drug? Analgesia
Conditions
Interventions
In the experimental group (A), a capsule of etoricoxib 120 mg was administered orally 30 minutes before the operation and the same identical capsule containing vitamin was given to ingest 4 hours afte
Treatment,Treatment
Group A: Etoricoxibs - Placebo,Group B: Placebo - Etoricoxibs
Sponsors
Department of Oral and Maxillofacial Surgery, Floor 13, faculty of Dentistry, Mahidol university
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists ASA : class I or II 2. Patients with presence of asymptomatic, bilaterally similar partially or totally impacted lower third molars as classified by the inclination according to the Winter classification, class and position according to the Pell and Gregory classification that requires flap opening, bone removal, and tooth separation during the operation 3. Age 18 to 30 years
Exclusion criteria
Exclusion criteria: 1. Patients with any history of allergy to non-steroidal anti-inflammatory drugs 2. Presence of systemic disease that contraindicates the surgical procedure such as uncontrolled hypertension, uncontrolled diabetes, asthma, and any pathological disease 3. Pre-existing acute infection and inflammation 4. Patients with a history of narcotic or alcohol abuse 5. Chronic opioid analgesic use 6. Pregnancy and lactating mother 7. The surgical time exceeding 120 minutes or any surgical complications occurred that would render the procedures non-comparable 8. Unable to follow the instructions or refusal to the follow-up appointments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of postoperative pain 6 months Numerical rating scale (NRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of total rescue analgesic requirement 6 months Total rescue analgesic requirement | — |
Countries
Thailand
Contacts
Public ContactSirichai Kiattavorncharoen
Faculty of dentistry, Mahidol university
Outcome results
None listed