photoaging by Glogau classification wrinkles at rest advanced photoaging obvious discoloration telangiectasia visible keratosis photodynamic therapy Chlorophyll photoaging ferrous chlotophyll red light
Conditions
Interventions
- Photodynamic therapy using 10% Fe-Chlorophyll (CU Pharmacy, in-house preparation) (CH-PDT) as a photosensitizer as a photosensitizer in 20 patients with clinically advanced stage of photoaging foll
Active Comparator Radiation
multiple-ascending dose study
Sponsors
Submitting for Ratchadapiseksompotch Research Fund
Eligibility
Sex/Gender
All
Age
35 Years to 95 Years
Inclusion criteria
Inclusion criteria: - Male or female who has severe photoaging by Glogau classification ( wrinkles at rest, advanced photoaging, obvious discoloration, telangiectasia, visible keratosis) - age 35-90 years old
Exclusion criteria
Exclusion criteria: - underlying of liver, kidney and cardiovascular disease - pregnancy or lactation women - has underlying skin diseases in the test area - atopic dermatitis and photosensitive rash - use of topical corticosteroids within 2 weeks, systemic corticosteroids within 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin reaction from photodynamic therapy in photoaging patients week 0, week 2, week 4 and week 6, week 10, week 14, week 18, week 22 and week 26 skin texture (Antera),skin reaction from photodynamic therapy in photoaging patients week 0, week 2, week 4 and week 6, week 10, week 14, week 18, week 22 and week 26 Skin thickness (Dermalab) | — |
Secondary
| Measure | Time frame |
|---|---|
| skin reaction from photodynamic therapy in photoaging patients week 0, week 2, week 4 and week 6, week 10, week 14, week 18, week 22 and week 26 safety (pain score by visual analog scale) | — |
Countries
Thailand
Contacts
Public ContactEinapak Boontaveeyuwat
King Chulalongkorn Memorial hospital and Faculty of Medicine, Chulalongkorn University
Outcome results
None listed