Three weekly doses(2ml) versus Single-shot (6ml) of intraarticular Hyaluronic acid injection, In patients with Knee Osteoarthritis A randomized controlled trial

efficacy of IA HA in patient with primary OA knee, single blinded randomized controlled trial,

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210720010

Enrollment

Registered

2021-07-20

Start date

2019-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thai people with primary OA of Knee, age above 40 years old,VAS score more than 4,Radiographic imaging of knee shows Knee Osteoarthritis Efficacy, Osteoarthritis, Knee, Hyaluronic acid injection, Three weekly doses, Single-shot

Interventions

Three weekly doses(2ml) of HA, anterolateral approach for knee injection without any anesthetic agent. ,Single-shot (6ml) of HA , anterolateral approach for knee injection without any anesthetic agen

Experimental Drug,Experimental Drug

Three weekly doses(2ml) , ostenyl,Single-shot (6ml) HA, ostenyl

Eligibility

Sex/Gender

All

Age

40 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1.Thai people with primary OA of Knee 2.Age above 40 years old 3.VAS score more than 4 4.Radiographic imaging of knee shows

Exclusion criteria

Exclusion criteria: 1.History of index Knee injection within 6 months 2.previous surgery of the index knee 3.Allergy to hyaluronic acid 4.History of inflammatory joint disease

Design outcomes

Primary

Measure	Time frame
visual analog scale 26 weeks after injection of the first dose. patient scale of pain 0-10	—

Secondary

Measure	Time frame
modified WOMAC scale 26 weeks after injection of the first dose. patient scale of pain 0-10	—

Countries

Thailand

Contacts

Public ContactWISSARUT SOONTORNWEERA

Police general hospital

champ615@hotmail.com0859293565

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026