Kidney transplant patient after 6 months of tranplant tacrolimus, pharmacokinetics, conversion, kidney transplant, 1:1
Conditions
Interventions
Post kidney transplant patients with stable allograft function currently on tacrolimus.
Treatment
Post kidney transplant patients
Sponsors
Ratchadaphiseksomphot Endowment Fund, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Post kidney transplant after 6 months or less than 10 years, 2. Mild to moderate immunological risk according to TTS (Thai Transplant Society), 3.Stable allograft function for the past 6 months by serum creatinie lesser than 3.0 mg per dL, 4. Currently on tacrolimus (BID TAC; Prograf, or OD TAC; Advagraf) no dose adjustment for 3 months
Exclusion criteria
Exclusion criteria: 1.Pregnancy, 2.Suspicious for acute allograft rejection or history of past rejection, 3.Patient with abnormal liver function test or history of cirrhosis, 4.Patients with active infection or currentlt admission due to other medical conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve at before and 4 weeks after medication conversion Trapezoidal model calculation,Tacrolimus whole blood concentration at time zero before and 4 weeks after medication conversion Chemiluminescent microparticle immunoassay | — |
Secondary
| Measure | Time frame |
|---|---|
| rejection follow up till 1 year after medication conversion allograft kidney biopsy,allograft function by serum creatinine every 1-3 months follow up till 1 year after medication conversion routein blood check up at out patient clinic ,adverse reaction any time, follow up till 1 year after medication conversion patients self report outcome | — |
Countries
Thailand
Contacts
Public ContactKanitha Tiankanon
Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University
Outcome results
None listed