The eligible COVID-19 patients who admit at Ramathibodi Hospitel, Ramathibodi Hospital and Ramathibodi Chakri Naruebodindra Hospital with new onset smell loss who capable to perform nasal irrigation themselves. COVID-19, Anosmia, Hyposmia, Budesonide
Conditions
Interventions
Patients will received 1 mg budesonide (Pulmicort Respules) and 4.5 g sodium chloride powder (Rama salt) to mix with 500 ml boiled water. Nasal irrigation will be performed with 125-mL each nostril, 2
Budesonide group,Saline group ,No irrigation group
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >18 years 2. Confirmed COVID-19 test positive with new onset of smell dysfunction 3. Patients who capable to perform nasal irrigation themselves
Exclusion criteria
Exclusion criteria: 1. Chronic use of nasal or systemic corticosteroids 2. History of smell loss before COVID-19 era 3. Previous history of rhinological diseases such as chronic rhinosinustis, nasal tumor, anatomical abnormalities of the nose 4. Pregnancy 5. The patients who refuse to enroll the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Smell sensation at baseline, post-irrigation 1 week, 2 weeks, 3 weeks, 4 weeks and 6 weeks. VAS score -VAS will be graded by patients which zero is completely normal smell sensation and ten is total loss of smell. ,Smell perception of specific odors (fish sauce, orange, coffee and jasmine ) at baseline, post-irrigation 1 week, 2 weeks, 3 weeks, 4 weeks and 6 weeks. Total Visual analog scale (VAS score) of smell perception of specific odors including 4 well-recognized odors for the Thai population. Specific odors include fish sauce, orange, coffee and jasmine ,Time to correct identification more than75% of odors and number of odors identification at each follow-up among each group baseline, post-irrigation 1 week, 2 weeks, 3 weeks, 4weeks and 6 weeks. Identification of 4 well-recognized odors for the Thai population will be assessed to evaluate time to recovery and number of odors identification at each follow-up among each group | — |
Secondary
| Measure | Time frame |
|---|---|
| Nasal symptoms at baseline, post-irrigation 1 week, 2 week, 3 week, 4 weeks and 6 week. Visual analog scale (VAS score) of nasal symptoms ,Side effects of Budesonide nasal irrigation at postoperative 1 week and 2 weeks. Pharyngeal and nasal burning/dryness will be evaluated. | — |
Countries
Thailand
Contacts
Public ContactJidapa Tragoonrungsea
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed