Mild cognitive impairment (MCI) Hyperbaric oxygen therapy,HBOT, Mild cognitive impairment, MCI, cognition improvement
Conditions
Interventions
Multiplace hyperbaric chamber at depth 2 ATA for 60 minutes per session 5 sessions per weeks for 8 consecutive weeks
Experimental Device
Hyperbaric oxygen therapy
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Somdej Prapinklao Foundation,Naval Medical Department
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. MCI according to DSM-5 Criteria 2. Age >= 60 3. Able to communicate after using visual aid device or auditory aid device
Exclusion criteria
Exclusion criteria: 1. Diagnosis of Dementia 2. Psychiatric illness 3. Psychoactive or antiepileptic drug use 4. Contraindication for HBOT 5. Currently on HBOT for other indication 6. Active severe systemic disease 7. Life expectancy within 1 year 8. Expected to start Anti-Dementia drug within 6 months 9. Active smoker or alcoholic drinker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive effects 0,10 wk,22 wk MMSE,Cognitive effects 0,10,22wk MoCA,Cognitive effects 0,10,22wk WRAML2,Cognitive effects 0,10,22wk TabCAT,Cognitive effects 0,10,22wk Grooved pegboard test,Cognitive effects 0,10,22wk CDR-SB,PET scan 0,10wk PET scan | — |
Secondary
| Measure | Time frame |
|---|---|
| Non-cognitive effects 0,10,22wk BADL,Non-cognitive effects 0,10,22wk IADL,Non-cognitive effects 0,10,22wk EQ-5D-5L,Non-cognitive effects 0,10,22wk NPI-Q,Side effect 0,10,22wk Adverse event questionaire | — |
Countries
Thailand
Contacts
Public ContactWeerasak Muangpaisan
Mahidol University
Outcome results
None listed