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A Multicenter, Randomized, Double-blind, Controlled trial of effects of using intravenous metoclopramide to increase mucosal visualization during endoscopy in patients with acute upper gastrointestinal bleeding

A Multicenter, Randomized, Double-blind, Controlled trial of effects of using intravenous metoclopramide to increase mucosal visualization during endoscopy in patients with acute upper gastrointestinal bleeding

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210708004
Enrollment
300
Registered
2021-07-08
Start date
2020-12-07
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Out-patient present in emergency department or in-patient has new inset upper gastrointestinal bleeding and received endoscopy within 24 hours of presentation or visited hospital UGIB, UGIH, gastrointestinal hemorrhage, gastrointestinal bleeding, endoscopy, hematemesis, GI bleeding

Interventions

Give metoclopramide 10 mg plus NSS 8 ml intravenous 10-30 mins before endoscopy ,Give NSS 10 ml intravenous 10-30 mins before endoscopy
Experimental Drug,Placebo Comparator No treatment
Metoclopramide arm,Placebo arm

Sponsors

Navamindradhiraj university Research Fund
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 95 Years

Inclusion criteria

Inclusion criteria: Out-patient present in emergency department or in-patient has new inset upper gastrointestinal bleeding and received endoscopy within 24 hours of presentation or visited hospital

Exclusion criteria

Exclusion criteria: History of metoclopramide allergy Underlying disease of psychiatric problem, Parkinson disease, Abnormal movement, Chronic kidney disease more than stage 4 Pregnancy or breast feeding Family history of Tardive dyskinesia

Design outcomes

Primary

MeasureTime frame
Clear mucosal visualization 10-30 mins Modified Avgerinos score

Secondary

MeasureTime frame
Repeat endoscopy 72 hours Day of repeat endoscopy,Diagnostic cause of bleeding Within endoscopy Diagnostic cause during endoscopy,Side effect of metoclopramide 24 hours Clinical presentation

Countries

Thailand

Contacts

Public ContactPAVEEYADA MANUPEERAPHANT

Navamindradhiraj university

paveeyada@nmu.ac.th022443480

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026