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Efficacy of a Combination of Ketamine and Morphine for Intravenous Patient Controlled- Analgesia in Upper Abdominal Surgery: A Prospective, Double-blind, Randomized Controlled Trial

Efficacy of a Combination of Ketamine and Morphine for Intravenous Patient Controlled- Analgesia in Upper Abdominal Surgery: A Prospective, Double-blind, Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210708002
Enrollment
78
Registered
2021-07-08
Start date
2015-01-12
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing elective upper abdominal surgery Ketamine, Morphine, Upper abdominal surgery, Intravenous patient-controlled analgesia

Interventions

received 1mg/ml of morphine as intravenous patient-controlled analgesia (IV-PCA) post-operation,received 1 mg of ketamine plus 1mg/ml of morphine as intravenous patient-controlled analgesia (IV-PCA) p
Active Comparator Drug,Active Comparator Drug
1mg/ml of morphine via IV PVA,1 mg of ketamine plus 1 mg /ml of morphine via IV PCA

Sponsors

Khon kaen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients 18-65 years of age who were classified as ASA physical status class I-II

Exclusion criteria

Exclusion criteria: Patients who had a history of chronic opioid use, had a history of chronic pain, had undergone a neuraxial block, had allergies to morphine or ketamine, suffered from psychiatric disorders, or were unable to operate the IV-PCA were excluded from the study

Design outcomes

Primary

MeasureTime frame
cumulative morphine consumption 48 hours Mg of morphine by IV PCA history device

Secondary

MeasureTime frame
pain score (at rest and during movement) at 1, 4, 12, 24, 36, and 48 hour post operative pain score at 1, 4, 12, 24, 36, and 48 hour post operative

Countries

Thailand

Contacts

Public ContactSaranyoo Nonphiaraj

Faculty of Medicine, Khon Kaen University

saranyoo@kku.ac.th043348390

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026