Corneal epithelial thickness measured by spectral domain optical coherence tomography can use for grading dry eye severity and have effect on treatment efficacy Corneal epithelial thickness, spectral domain optical coherence tomography, dry eye disease
Conditions
Interventions
1.Optical coherence tomography group (Dry eye severity assessment by corneal epithelial thickness measurement)
Corneal epithelial thickness variance less than 4 categorized as Mild to moderate dry
Experimental Device,No Intervention Other
Optical coherence tomography group,Control group
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Participant diagnosed Dry eye by TFOS DEWS II criteria - DEQ-5 Questionnaire not less than 6 with one of the followings - Non-invasive Tears film break up time < 10 second - Ocular surface staining at cornea >5 spot or conjunctiva > 9 spot or eyelid staining length not less than 2 mm and not less than 25 % width
Exclusion criteria
Exclusion criteria: -other ocular surface disease eg. Epithelial basement membrane dystrophy, Corneal scar, Herpes infection, Recurrent corneal erosion -eyelid or blinking problem -other ocular medication eg. glaucoma medication -contact lens wear -systemic medication eg.Anti-histamine, Estrogen replacement therapy, Anti-depressant, Isotretinoin -history of ocular trauma or ocular surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eye dryness at 1 and 3 month after dry eye treatment Tear film break up time | — |
Secondary
| Measure | Time frame |
|---|---|
| Eye dryness at 1 and 3 month after dry eye treatment DEQ-5 score,Eye dryness at 1 and 3 month after dry eye treatment Corneal fluorescein stain grading | — |
Countries
Thailand
Contacts
Public ContactPratan Piyasoonthorn
Chulabhorn hospital
Outcome results
None listed