Patients with cardiogenic shock require vasopressor agents or inotrope agents to restore and maintain blood pressure and cardiac output. cardiogenic shock, norepinephrine, dopamine, 28-days mortality
Conditions
Interventions
patients who receieved norephinephrine for treatment of cardiogenic shock.,patients who receieved dopamine for treatment of cardiogenic shock.
Treatment,Treatment
Norepinephrine group,dopamine group
Sponsors
Faculty of Pharmaceutical Sciences, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with cardiogenic shock who admitted to the CCU and ICCU at King Chulalongkorn Memorial Hospital between 1 January 2014 to 31 December 2021. All adults patients age greater than 18 who receieved norepinephrine or dopamine. Patients diagnosed with cardiogenic shock were identified by the presence of International Classification of Disease, tenth revision, ICD 10th code R570 in the list of diagnosed generated during the course of their hospital stay or identified by clinical criteria (SBP< 90 mmHg despite adequate amount of fluids had been administration and if there were signs of tissue hypoperfusion (e.g. altered mental state, cold extremities, urine output of < 0.5 ml/kg/h or < 30 ml/h, arterial blood pH < 7.35, arterial blood lactate > 2 mmol/L or serum creatinine rising at least 0.3 mg/dL or increasing more than 1.5 to 1.9 times of baseline serum creatinine) or hemodynamic criteria (e.g. cardiac index less than 2.2 L/min/m2 and pulmonary capillary wedge pressure more than 15 mmHg) in 24 to 48 hours before received norepinephrine or dopamine.
Exclusion criteria
Exclusion criteria: 1. Shock from other cause such as hypovolemic shock, sepsis shock or anaphalaxis shock in 24 to 48 hours before received norepinephrine or dopamine. 2. Patients with cardiogenic shock who recieved both norepinephrine and dopamine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-days mortality rate at 28 days after diagnosed cardiogenic shock Percentage | — |
Secondary
| Measure | Time frame |
|---|---|
| The use epinephrine rescue therapy with in 28 days after diagnosed cardiogenic shock Percentage,Arrhythmia with in 28 days after diagnosed cardiogenic shock Percentage,Timing before use of mechanical circulatory support with in 28 days after diagnosed cardiogenic shock Hours,Length of stay with in 28 days after diagnosed cardiogenic shock Days,Cardiac index at H0, H6, H12, H24, H48, H72 after pulmonary artery catheter insertion L/min/m2,Mean pulmonary capillary wedge pressure at H0, H6, H12, H24, H48, H72 after pulmonary artery catheter insertion mmHg,Syetemic vascular resistance at H0, H6, H12, H24, H48, H72 after pulmonary artery catheter insertion dyne x sec x cm-5 | — |
Countries
Thailand
Contacts
Public ContactSuthida Chanchenchop
Faculty of Pharmaceutical Sciences, Chulalongkorn University
Outcome results
None listed