Changes in Brain Glucose Metabolism as Evaluated by F-18 FDG PET/CT in Autistic Patients after Transcranial Direct Current Stimulation, Non Randomized Controlled trial

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210705005

Enrollment

Registered

2021-07-05

Start date

2021-07-07

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Disorder Autism Spectrum Disorder, ASD, Transcranial Direct Current Stimulation, F-18 FDG PET-CT

Interventions

Transcranial direct current stimulation(tDCS) was applied in 8 autistic scalps using a 35 cm2, pair of surface sponge electrodes with gel (Soterix EASYpad, New York, USA) and was delivered through ba

Experimental Device,No Intervention Device

Transcranial direct current stimulation 5 session,Dose not receive transcranial direct current stimulation

Eligibility

Sex/Gender

All

Age

15 Years to 30 Years

Inclusion criteria

Inclusion criteria: (a) mild to moderate autistic symptoms (CARS score 30-36.5) which could stay still in the scanner; (b) aged between 15 and 30; (c) the caregiver consents to participate in the research and can follow up the stimulation results; (d) a healthy volunteer aged between 15 and 30.

Exclusion criteria

Exclusion criteria: (a) wound or skin abrasion at the area under electrode; (b) on metallic device; (c) skull defect; (d) severe neurological disorders such as brain tumor, intracranial infection; (e) drug abuse; (f) uncooperative parents and caregivers; (f) uncontrollable epilepsy; (g) use of herbal remedies and other alternative therapies such as craniosacral manipulation or hyperbaric oxygen therapy; and (h) claustrophobia

Design outcomes

Primary

Measure	Time frame
brain metabolism of the autistic patient at 1 day before treatment F-18 FDG PET/CT scan,ATEC score at day 5 and day 14 Questionnaire	—

Secondary

Measure	Time frame
change in brain metabolism after 5 sessions of anodal tDCS at 1 week before treatment and immediately after treatment F-18 FDG PET/CT scan, correlation between ATEC social subscale changed and regional brain glucose metabolism changed immediately after treatment F-18 FDG PET/CT scan	—

Countries

Thailand

Contacts

Public ContactParadee Auvichayapat

Khon Kaen University

aparad@kku.ac.th0896222624

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026