Nail psoriasis patients with at least 4 fingernails involvement. nail psoriasis, psoriatic nail, botulinum toxin injection
Conditions
Interventions
A psoriatic nail will be injected intralesional abobotulinumtoxinA (Dysport) 0.05 ml/site (7.5 unit) in a psoriatic nail at 0 week (0.9% Sodium chloride 2 ml dilutes abobotulinumtoxinA 300-unit vial).
Experimental Drug,Active Comparator Drug,Active Comparator Drug,No Intervention No treatment
Sponsors
Chulabhorn International College of Medicine, Thammasat University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patient aged at least 20 years old. 2. Psoriatic nail patients who have at least 4 psoriatic nails. 3. Each enrolled nail has target NAPSI score at least 3 points.
Exclusion criteria
Exclusion criteria: 1. Patients refusel to participate the study 2. Patients are using topical nail therapies within 2 weeks. 3. Patients are receiving oral therapies within 4 weeks. 4. Patients have active nail infection. 5. Patient with sensitivity or allergy to constituents of the botulinum toxin product, vitamin D , corticosteroid, cows milk protein or lidocaine 6. Patient with neuromuscular disorder or peripheral motor neuropathic disease (e.g. amyotrophic lateral sclerosis, myasthenia gravis, Lambert Eaton syndrome, myopathies) 7. Pregnancy or breastfeeding 8. Unrealistic expectation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nail psoriasis at 4 and 6 months after end of the first intervention target NAPSI score,Pain of nail injection at 0 and 8 weeks of intervention pain score 0-10,Complication of nail psoriasis treatment at 8, 16, and 24 weeks side effect | — |
Secondary
| Measure | Time frame |
|---|---|
| Satisfaction of nail psoriasis improvement at 8, 16, and 24 weeks Patient's satisfaction 0-4 | — |
Countries
Thailand
Contacts
Public ContactSuthima Srisinlapakig
Chulabhorn International College of Medicine Thammasat University
Outcome results
None listed