Symmetrical atrophic acne scars on both sides of the face fractional CO2 laser, platelet-rich plasma, PRP, ablative carbon dioxide fractional laser atrophic acne scars
Conditions
Interventions
After fractional CO2 laser is done on randomized side of the face(only half face), autologous platelet-rich plasma will be injected intradermally only on the area with atrophic acne scars. Injection s
Experimental Device,Active Comparator Device
Fractional carbon dioxide laser combined with autologous platelet-rich plasma intradermal injection,fractional CO2 laser(alone)
Sponsors
Astraco Medical Networks Ltd.
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Subjects age 18-50 years old who have symmetrical atrophic acne scars on both sides of the face with mild to severe severity of acne scars. 2. Duration of acne scar from 6 months to 10 years. 3. Subjects are willing to comply with study protocol and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects with moderate to severe acne vulgaris (IGA3-4) or currently have active and uncontrolled acne vulgaris. 2. Female subjects who are currently in pregnancy or breastfeeding. 3. Subjects who have rash, infection or other dermatologic diseases on face. 4. Dermatologic procedural treatments within previous 3 months before study enrollment. 5. Subjects with active herpes infection, bleeding diathesis, cancer, HIV or HBV infection. 6. Subjects who have taken isotretinoin within previous 6 months. 7. Subjects who are currently on antiplatelet or anticoagulant drugs. 8. Subjects woth predisposition to keloid formation. 9. Subjects who cannot comply with the study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical improvement rate (quartile scale) of atrophic acne scar 0, 4, 8, 12 and 20 weeks Comparing pre- and post- treatment facial photography | — |
Secondary
| Measure | Time frame |
|---|---|
| Wound healing promotion day 3 and day 7 post injection 4-point grading score, duration of post-procedural erythema, swelling and scabs,Adverse effects day0, day3, day7, week4,8,12,20 Visual analog scale(VAS) 1-10 of each adverse effects including edema, erythema,scabs and postinflammatory hyperpigmentation,patient satisfaction score week20 Visual analog scale(VAS) 1-10 | — |
Countries
Thailand
Contacts
Public ContactRatchathorn Panchaprateep
Dermatology Division, Faculty of Internal Medicine
Outcome results
None listed