Patients who were suffering from chronic nasal obstruction secondary to inferior turbinate hypertrophy who failed at least 3-month medication therapy to control nasal obstructive symptom. topical decongestant, turbinoplasty, oxymetazoline, postoperative care
Conditions
Interventions
Patients receive physiologic saline nasal
irrigation with 125-mL, 4times daily
and oxymetazoline hydrochloride 0.05%
nasal spray, 1puff to each nostril 3 times
a day for 7 days, post-operative tubinec
Active Comparator Drug,Placebo Comparator Drug
Oxymetazoline nasal spray group,Control group
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>18years 2. Patients who were suffering from chronic nasal obstruction secondary to inferior turbinate hypertrophy who failed at least 3-month medication therapy to control nasal obstructive symptom and plan to go on the turbinate reduction procedure are enrolled into the study.
Exclusion criteria
Exclusion criteria: 1. Any other inflammatory or infectious diseases or tumor of sinonasal cavities i.e. Wegener's disease, cystic fibrosis and lymphoma 2. Clinical or radiologic or endoscopic evidence of rhinosinusitis with or without nasal polyp 3. Clinical or radiologic or endoscopic evidence of severe septal deviation without correction 4. Rhinitis medicamentosa 5. Long term vasoconstrictor drug use 6. Disorder of nasal valve 7. Pregnancy 8. The patients who refuse to enroll the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nasal obstructive symptom preoperative, postoperative day1-day7(mean VAS score), at 2 week and at 1 month Nasal Obstruction Symptom Evaluation (NOSE),severity of nasal obstruction, frequency of nasal obstruction, rhinorrhea, sneezing, itchy nose, headache, hyposmia, snoring preoperative, postoperative day 1-day7 (mean VAS score), 2 week and at 1 month Visual analog scale (VAS score) | — |
Secondary
| Measure | Time frame |
|---|---|
| Crusting postoperative 1 week, 2 week and at 1 month Crusting score,bleeding severity postoperative day 1-day 7(mean score) bleeding severity grading ,Inferior turbinate size preoperative, postoperative 1 week, 2 week and 1 month 4-point ordinal scale,Pain postoperative day 1 -day7 (mean score) Pain score,nasal airway resistance preoperative, postoperative 1 week and 1 month Anterior rhinomanometry,Side effects of decongestant preoperative, postoperative 1 week Heart rate and blood, Topical effects such as burning, stinging, irritation and dryness in the nose will be recorded pressure,Mucociliary function preoperative and postoperative 1 month saccharin test | — |
Countries
Thailand
Contacts
Public ContactJidapa Tragoonrungsea
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Outcome results
None listed