Pediatric sepsis patients Intensive care units, pediatirc Sepsis Septic shock Pharmacokinetics
Conditions
Interventions
Standard dosing of vancomycin 15 mg/kg/dose intravenous infusion over 1 hours every 6 hours (total daily dose 60 mg/kg/day). Maximum daily dose in this group will be limited at 3000 mg/day.,A loading
Active Comparator Drug,Experimental Drug
Standard dose,Loading dose
Sponsors
Kritsaporn Sujjavorakul
Eligibility
Sex/Gender
All
Age
3 Months to 18 Years
Inclusion criteria
Inclusion criteria: 1. Age 3 months to 18 years at the day of the first dose vancomycin 2. Pediatric sepsis patients 3. Informed consent by one parent or the legal guardian
Exclusion criteria
Exclusion criteria: 1. Receiving extracorporeal organ support including hemodialysis, peritoneal dialysis (PD), continuous renal replacement therapy (CRRT), plasmapheresis, blood purification, artificial liver support systems, and extracorporeal membrane oxygenation (ECMO) 2. Previous vancomycin treatment within 1 weeks prior to the day of study in subject with normal kidney function at baseline or within 4 weeks prior to the day of study in subject with renal impairment. 3. Stage 3 AKI 4. untreatable underlying diseases expected to result in death within 90 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC/MIC 6 hours after first dose First order pharmacokinetic equations | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute kidney injury 2 weeks modified Schwartz equation,AUC steady state 2 days First order pharmacokinetics equation,Mortality 90 days Count | — |
Countries
Thailand
Contacts
Public ContactKritsaporn Sujjavorakul
King Chulalongkorn Memorial Hospital
Outcome results
None listed