Idiopathic Parkinson'
Conditions
Interventions
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria for healthy participants. 1. No history of neurological or psychological problems, 2. No history of musculoskeletal problems and osteoporosis, 3. Able to follow command (score more than 23 by Mini Mental State Examination or MMSE Thai version 2002) Inclusion criteria for PD participants. 1. Diagnosed with idiopathic PD with stable motor symptoms during ON phase of medication treatment, 2. Hoehn & Yahr stage range from II to IV, 3. Able to standing independently, 4. Able to follow command (score more than 23 by Mini Mental State Examination or MMSE Thai version 2002) Inclusion criteria for PD with PA and FNF participants. The same criteria as PD participants and presents of additional criteria as followings, 1. Diagnosed with one type of PD related PA such as camptocormia, antecollis, and Pisa syndrome, or presenting postural abnormalities evaluated by 2 to 4 score in posture item of MDS-UPDRS, 2. Present of FNF more than 40 degrees from vertical reference line (craniovertebral angle less than 60 degrees)
Exclusion criteria
Exclusion criteria: Exclusion criteria for healthy participants. 1. Present of FNF more than 40 degrees from vertical reference line (craniovertebral angle less than 60 degrees) 2. Presenting of pain or problems which limit cervical range of motion Exclusion criteria for PD participants. 1. Diagnosed with secondary parkinsonism from other causes 2. Presenting severe dyskinesia (screened by MD-UPDRS score 3 to 4) 3. Presenting on-off fluctuations (screened by motor fluctuation part of MD-UPDRS score) 4. Have history of osteoporosis, neurological or psychological dysfunction 5. Have history of spinal surgery or spinal diseases which limited spinal mobility such as ankylosing spondylitis, vertebral fractures, radiculopathy, degenerative spondylosis, spondylolisthesis, or scoliosis, 6. Have history of muscle weakness problems such as myasthenia gravis, motor neuron disease, polio or post-polio syndrome, myositis, amyloid or thyroid myopathy, 7. Presenting symptomatic joint diseases or soft tissue injuries which cause of limited ROM such as rheumatoid arthritis, gouty arthritis, degenerative osteoarthritis or muscle pain, 8. Unable to stand independently, 9. Present of FNF more than 40 degrees from vertical reference line (craniovertebral angle less than 60 degrees), 10. Diagnosed with one type of PD related PA such as camptocormia, antecollis, and Pisa syndrome, or presenting postural abnormalities evaluated by 2-4 score in posture item of MDS-UPDRS, 11. Have history of DBS surgery or received muscle relaxants such as lidocaine and botulinum toxin for PA treatment, 12. Psychiatric illness, alcohol or substance abuse during the time of study, 13. Sustained and poor controlled depression or anxiety (screened by Thai Hospital Anxiety and Depression Scale or Thai HADS) Exclusion criteria for PD with PA and FNF participants 1. Diagnosed with secondary parkinsonism from other causes 2. Presenting severe dyskinesia (screened by MD-UPDRS score 3-4) 3. Presenting on-off fluctuations (screened by motor fluctuation part of MD-UPDRS score) 4. Have history of osteoporosis, neurological or psychological dysfunction 5. Have history of spinal surgery or spinal diseases which limited spinal mobility such as ankylosing spondylitis, vertebral fractures, radiculopathy, degenerative spondylosis, spondylolisthesis, or scoliosis 6. Have history of muscle weakness problems such as myasthenia gravis, motor neuron disease, polio or post-polio syndrome, myositis, amyloid or thyroid myopathy 7. Presenting symptomatic joint diseases or soft tissue injuries which cause of limited ROM such as rheumatoid arthritis, gouty arthritis, degenerative osteoarthritis or muscle pain 8. Unable to stand independently 9. Have history of DBS surgery or received muscle relaxants such as lidocaine and botulinum toxin for PA treatment 10. Psychiatric illness, alcohol or substance abuse during the time of study 11. Sustained and poor controlled depression or anxiety (screened by Thai Hospital Anxiety and Depression Scale or Thai HADS)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tissue biomechanical properties and viscoelasticity before intervention, end of first session intervention, end of intervention program, 2 weeks after intervention program passive tone, dynamic stiffness, elasticity, relaxation time, and creep, which measured by myotonometry (MYOTON) | — |
Secondary
| Measure | Time frame |
|---|---|
| postural alignment before intervention, end of first session intervention, end of intervention program, 2 weeks after intervention program sagittal head tilt (HT), craniovertebral angle (CV), shoulder-C7 angle (SH), and thoracic kyphosis (TK) angles that observed by sagittal view photogrammetry.,cervical range of motion before intervention, end of first session intervention, end of intervention program, 2 weeks after intervention program degree of all cervical motion directions, flexion, extension, lateral flexion , and rotation that measured by Cervical range of motion device ,postural and rigidity score before intervention, end of first session intervention, end of intervention program, 2 weeks after intervention program Using of The Movement Disorder Society - Unified Parkinsons disease rating scale (MDS-UPDRS) ,Levels of activity of daily living before intervention, end of intervention program, 2 weeks after intervention program Using of The Movement Disorder Society - Unified Parkinsons disease rating scale (MDS-UPDRS) | — |
Countries
Thailand
Contacts
Faculty of Medicine Siriraj Hospital, Mahidol University