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Efficacy of Benzydamine Hydrochloride in Reducing Postoperative Sore Throat after General Anesthesia with Endotracheal Tube: a Randomized Controlled Trial

Efficacy of Benzydamine Hydrochloride in Reducing Postoperative Sore Throat after General Anesthesia with Endotracheal Tube: a Randomized Controlled Trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210610002
Enrollment
180
Registered
2021-06-10
Start date
2021-07-05
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative sore throat benzydamine hydrochloride, endotracheal tube, general anesthesia, postoperative sore throat

Interventions

Spraying Benzydamine hydrochloride over the oropharyngeal cavity and the endotracheal cuff.,Spraying Benzydamine hydrochloride over the endotracheal cuff. Spraying placebo over the oropharyngeal cavit
oropharyngeal cavity and endotracheal cuff,Benzydamine hydrochloride
endotracheal cuff,Control

Sponsors

Rajavithi hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing surgery under general anesthesia with oral endotracheal intubation, elective surgery. 2. The duration of the surgery is not more than 4 hours. 3. ASA Physical status 1-3

Exclusion criteria

Exclusion criteria: 1. Pregnant women or patients at risk for aspiration pneumonia 2. The patient has a history or has been assessed as difficult intubation 3. The patient undergoing head, face, and neck surgery 4. Currently has a sore throat or have a sore throat within 1 week before surgery 5. Allergy to benzydamine hydrochloride or other NSAIDs. 6. On steroids or lidocaine before surgery 7. Has limited communication

Design outcomes

Primary

MeasureTime frame
The incidence of postoperative sore throat The first 24 hours after surgery Patient reported outcome with a four-point verbal categorical rating scale.

Secondary

MeasureTime frame
Side effects of benzydamine hydrochloride The first 24 hours after surgery Patient reported outcome

Countries

Thailand

Contacts

Public ContactThanaphirat Mamaethong

Rajavithi hospital

thanaphirat.ma@rsu.ac.th66896915609

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026