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The effect of Fermentable, Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAPs) diet on upper gastrointestinal (GI) function in patients with overlapping irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD)

The effect of Fermentable, Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAPs) diet on upper gastrointestinal (GI) function in patients with overlapping irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD)

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210608005
Enrollment
8
Registered
2021-06-08
Start date
2020-10-12
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effects of FODMAPs diet on transient lower esophageal sphincter relaxation (TLESR), intestinal gas production, and postprandial GERD and other GI symptoms in overlapping IBS-GERD patients. non-constipation irritable bowel syndrome, GERD, rice, wheat, Low FODMAPs, High FODMAPs, intestinal gas, hydrogen, gastrointestinal symptoms

Interventions

Wheat flour and cooked as a noodle. The amount of CHO: protein: fat contents in a serving size of wheat noodle were 42: 32: 14 gm,The amount of CHO: protein: fat contents in rice noodle as a serving s
Placebo Comparator No treatment,Placebo Comparator No treatment
Study meal A ,Study meal B

Sponsors

The Gastroenterological Association of Thailand (GAT)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. 18-65 years old, 2. non-constipation type IBS patients according to the Rome III criteria, 3. typical GER (troublesome heartburn and/or regurgitation) symptoms, 4. Informed consent

Exclusion criteria

Exclusion criteria: 1. Previous history of abdominal surgery, 2. pregnancy, 3. major psychological disorders, 4. history of allergy to the test meals, 5. Chronic obstructive pulmonary disease (COPD), asthma, 6. Celiac disease, gluten and wheat allergy was excluded by a serologic test (negative serum immunoglobulin A anti-tissue transglutaminase; tTG antibody) and a specific skin prick test for gluten and wheat, 7. Probiotic supplements, prokinetics, laxatives, antibiotics or medications that affect GI functions and symptoms in the preceding 4 weeks prior to the study

Design outcomes

Primary

MeasureTime frame
The number of TLESR 2 hours after lunch ingestion High resolution esophageal manometry (HRM) catheter—

Secondary

MeasureTime frame
Hydrogen and Methane gas concentration, GI symptom scores 8 hours after breakfast ingestion Hydrogen breath test, Visual analog scale—

Countries

Thailand

Contacts

Public ContactSuppawatsa Plaidum

Division of Gastroenterology

vavai_vv@hotmail.com0814412375

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026