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Effects of Nasal Continuous Positive Airway Pressure Compared with High Flow Nasal Cannula on The Coordination Between Swallowing and Breathing in Post-extubation Patients, a Randomized Crossover Study

Effects of Nasal Continuous Positive Airway Pressure Compared with High Flow Nasal Cannula on The Coordination Between Swallowing and Breathing in Post-extubation Patients, a Randomized Crossover Study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
TCTR
Registry ID
TCTR20210607003
Enrollment
16
Registered
2021-06-07
Start date
2021-12-08
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Swallowing- breathing coordination in postextubation patients using nasal continuous positive airway pressure and high flow nasal cannula nasal continuous positive airway pressure high flow nasal cannula swallowing and breathing coordination postextubation patients

Interventions

Using continuous positive airway pressure via nasal mask. Setting CPAP was 5 cmH2O. FiO2 was adjusted to maintain SpO2 at more than 95%.,Using high flow nasal cannula. Setting was a flow rate at 50
Experimental Device,Experimental Device
nasal continous positive airway pressure,high flow nasal cannula

Sponsors

Ratchadapisek Research Funds, Faculty of Medicine, Chulalongkorn University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. intubated for more than 48 hours and extubated within 48 hours 2. able to maintain adequate oxygen saturation by using low flow oxygen cannula 1-5 LPM 3. have stable vital signs 4. pass the modified swallowing test with the score of more than 3 points

Exclusion criteria

Exclusion criteria: 1. not cooperative 2. have contraindication for enteral feeding 3. cerebrovascular disease, neuromuscular disease or muscle weakness 4. head and neck cancer 5. structural abnormalities of oral cavity or pharynx 6. history of surgery within oral cavity or pharyngeal area 7. delirium 8. previous diagnosis of dysphagia 9. skin lesions which interfered with EMG monitoring 10. have automated implantable cardioverter-defibrillator or permanent pacemaker

Design outcomes

Primary

MeasureTime frame
The frequency of each pattern of the timing of swallowing in relation to respiratory phases about 5 minutes while using the devices (HFNC and CPAP) The swallowing was recorded by surface electromyography (EMG) of swallowing muscles and respiratory phases were monitored by ECG-derived respiratory signals and surface EMG of respiratory muscles.

Secondary

MeasureTime frame
Factors affect swallowing-breathing coordination during the experiment Clinical data and baseline charachteristic of participants will be collected from electronic medical record

Countries

Thailand

Contacts

Public ContactSawita Cowawintaweewat

Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University

sawita.c20@chula.md0818548589

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026