A randomized split-face double-blind control trial of the Efficacy of Hydroquinone-free skin brightening serum (Melacare) on Improvement of Melasma versus placebo in THAIS

Efficacy of Hydroquinone-free skin brightening serum (Melacare) on Improvement of Melasma: A randomized split-face double-blind control trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20210604008

Enrollment

Registered

2021-06-04

Start date

2021-01-31

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Efficacy of of hydroquinone-free skin brightening serum (Melacare) on improvement of melasma compare to placebo in female 30-60 years Melasma, mMASI, Mean Melanin Index, Natural additives

Interventions

Melacare serum contains N-acetyl glucosamine, Tranexamic acid, Heaven white, Niacinamide, Alpha arbutin, Fish collagenDeionized water, Isoprene glycol, Rhamnosoft hp 1.5p, Microcare phc ,Placebo seru

Experimental Other,Placebo Comparator No treatment

Melacare serum,Placebo

Eligibility

Sex/Gender

Female

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Thai female diagnosed with melasma, 2. Fitzpatrick skin type III-V, 3. Age between 30-60 years old, 4. Volunteers apply sunscreen regularly every day, 5. Volunteers have voluntarily agreed to participate in the trial of 6 weeks and signed a written consent to treatment.

Exclusion criteria

Exclusion criteria: 1. Volunteers with the history of melasma treatment whether by topical, oral, or other tools and had not stopped receiving such treatment at least 4 weeks prior to the start of the study, 1.1. Topical drugs include drugs containing corticosteroids, vitamin A derivatives, hydroquinone, tranexamic acid, or whitening agents such as kojic acid, arbutin, licorice extract, ascorbic acid, azelaic acid. etc., 1.2 Oral medications including drugs or supplements that affect skin tone, 1.3 Tools such as exfoliating agents and various types of laser treatment of melasma, 2. Volunteers who are pregnant or breastfeeding or is likely to become pregnant, 3. Volunteers with a history of hormonal disorders or taking hormone-adjusting drugs, 4. Volunteers used oral contraceptives, 5. Volunteers had a history of allergy to the ingredients in the serum, including N-acetyl glucosamine, Tranexamic acid, Heaven white, Niacinamide, Alpha arbutin, Fish collagen, 6. Volunteers engage in occupations or jobs that require unavoidable exposure to the sun for long periods of time per day on a regular basis.

Design outcomes

Primary

Measure	Time frame
Skin color 4 weeks Mean Melanin Index (MMI)	—

Secondary

Measure	Time frame
The severity of melasma 4 week Modified Melasma Area and Severity Index (mMASI) score	—

Countries

Thailand

Contacts

Public ContactSirinya Chetanachan

Dhurakij Pundit University

sirinya711@gmail.com0814381034

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026