Postoperative pain severity after third molar surgery will be moderate to severe pain during 6-12 hr. postoperatively. Analgesic drugs used after surgery do not be effective pain reduction. Postoperative pain , third molar surgery
Conditions
Interventions
Ibuprofen 400 mg 1 tab orally and paracetamol 500 mg 1 tab orally before operation 1 hour.,One placebo (starch) mimic ibuprofen 400 mg 1 tab orally and one placebo (starch) mimic paracetamol 500 mg 1
Experimental Drug,Placebo Comparator Drug
ibuprofen 400 mg combined paracetamol 500 mg,Two placebos (mimic ibuprofen and paracetamol in each)
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1. Healthy (American Society of Anesthesiologists (ASA) classification I and II) 2. Age 18 to 30 years 3. Clear indication for removal of lower third molars 4. Moderate difficulty of lower third molar (Pederson 's difficulty index 5 to 6 score) 5. An absence of periodontal disease, infection, swelling prior to surgery
Exclusion criteria
Exclusion criteria: 1.A history of hypersensitivity to NSAIDs and/or paracetamol 2.Taking analgesic medications, such as aspirin, paracetamol, NSAIDs, opioids, or any other agents that could confound the analgesic and safety/tolerability responses; the washout periods were between 24 hours and 2 weeks, depending on the half-life of the respective medications. 3.Taking medications known to interact with the study medications. 4.Patients with a history of severe asthma, gastrointestinal disorders such as gastric ulceration; hematologic, renal or hepatic disease; immunosuppressive disorder; neurological disorder affecting pain perception 5.Pregnant or lactating women 6.Smoker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score (visual analog scale) 5 years millimeter,Number of pain free patient 5 years number,Time at first requirement for rescue medications 5 years minute,Number of patients who received rescue medications 5 years number,Drug satisfaction (visual analog scale) 5 years millimeter | — |
Secondary
| Measure | Time frame |
|---|---|
| Facial swelling 5 years millimeter,Mouth opening 5 years millimeter | — |
Countries
Thailand
Contacts
Public ContactPichai Vittayakittipong
Faculty of Dentistry, Prince of Songkla University
Outcome results
None listed