Acne vulgaris patients who can be treated by comedo extraction topical timolol, tetrachlorodecaoxide, oxymetazoline, post extraction erythema, post acne erythema, comedone extraction
Conditions
Interventions
Topical 0.5% Timolol maleate:
Subjects will be performed comedo extraction by the same dermatologist throughout the study period. After the extraction, fifteen subjects who are assigned to be treated
Experimental Drug,Experimental Drug,Experimental Drug
Topical 0.5% Timolol maleate,topical Tetrachlorodecaoxide,0.05% oxymetazoline hydrochloride
Sponsors
None
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. subjects age 18-50 years old 2. subjects with acne vulgaris that can be treated by comedo extraction 3. symmetrical acne vulgaris on both sides of face, defined as less than 10 comedones and 5 inflammatory papules differed between 2 sides of face, and less than 10% erythema score difference between 2 sides of face, measured by Visia
Exclusion criteria
Exclusion criteria: 1. Subjects with history of rosacea or other active dermatitis on the treatment site 2. Subjects with history of hypertrophic scars or keloid 3. Previously known allergic reaction to timolol, tetrachlorodecaoxide and oxymetazoline 4. Subjects with past medical history of hypertension, asthma, cardiovascular disease, cerebrovascular disease, vascular disease, close angle glaucoma, hypotension or postural hypotension 4. A pregnant or breast feeding subjects
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Erythema score baseline, 1 day, 3 days, 7 days and 1 month after treatment Visia image analysis for erythema score evaluation,Erythema, edema and crusting score baseline, 1 day, 3 days, 7 days and 1 month after treatment Physician's assessment by 4-point grading scale | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects after treatment such as pain score, tightness score, pruritus score, patient satisfaction score baseline, 1 day, 3 days, 7 days and 1 month after treatment Subject's assessment by visual analogue scale(VAS),Satisfaction score after treatment 1 day, 3 days, 7 days and 1 month after treatment Subject's assessment by visual analogue scales(VAS) | — |
Countries
Thailand
Contacts
Public ContactChanat Kumtornrut
Division of Dermatology, Faculty of Medicine, Chulalongkorn university
Outcome results
None listed