To study the results of local injection of tranexamic acid on surgical field quality during endoscopic sinus surgery in chronic rhinosinusitis patients Endoscopic sinus surgery, FESS, Tranexamic acid, surgical field quality
Conditions
Interventions
1. A statistician makes 47 sealed envelopes for 47 subjects using block randomization (computerized program by STATA) - each sealed envelope will specify which side of nose will receive intervention o
Active Comparator Drug
Tranexamic acid
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Being candidate for FESS based on EPOS 2020 criteria 2. Age 18 to 60 years 3. Hemoglobin > 10 mg/dl 4. Normal INR, PT, PTT
Exclusion criteria
Exclusion criteria: 1. Having diathesis hemorrhage such as hemophilia 2. Having history of thrombosis 3. Acute or chronic renal failure 4. Using heparin during 48 hours before surgery 5. Using aspirin during 7 days before surgery 6. Allergy to TXA 7. Cirrhosis 8. Pregnancy 9. Having a cardiac stent 10. Having a nasal tumor 11. Patients who are unable to undergo surgery due to the opinion of an internist 12. Refuse to participate in OR withdraw from the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The quality of surgical field at 15, 30 and 45 minutes after the start of surgery Boezaart surgical field grading sysyem, Wormald surgical field grading system | — |
Secondary
| Measure | Time frame |
|---|---|
| Operative blood loss at 15, 30 and 45 minutes after the start of surgery ml,Duration of surgery at the end of the operation of each side of the nose minute,Side effects 24 hours after operation questionnaire | — |
Countries
Thailand
Contacts
Public ContactKshidej Bongsabhikul
Faculty of Medicine, Mahidol University
Outcome results
None listed