Oily facial skin subjects Sebum analysis, licochalcone A, 1,2-decanediol, L-carnitine, salicylic acid, oily skin, facial sebum
Conditions
Interventions
Moisturizer containing licochalcone A,1 2 decanediol, L carnitine, and salicylic acid is a cosmeceutical product (medical skin care). Subjects regularly apply 1 fingertip (equivalent to 2.5 grams) of
Experimental Other
Moisturizer containing licochalcone A, 1 2 decanediol, Lcarnitine, and salicylic acid
Sponsors
Beiersdorf Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.Healthy men or women with the age of 18 to 40 years old. 2. Subjects are assessed by the dermatologist to have oily facial skin with sebum amount more than 105 microgram/cm2 measured by Sebumeter. 3. Participants must willingly give informed consent
Exclusion criteria
Exclusion criteria: 1. Subjects with underlying diseases such as cardiac disease, liver disease or kidney disease, or currently taking medications for health issue 2. History of allergic reaction to any components of the product 3. Subjects who have rash or other dermatologic diseases on their faces 4. History of systemic acne treatment including isotretinoin and spironolactone use within 3 months before study enrollment 5. History of oral contraceptives or anti-androgenic drug use within 3 months before study enrollment 6. History of dermatologic procedural treatment within 6 months before study enrollment. 7. History of topical corticosteroid use on the face within 2 weeks and systemic corticosteroid within 4 weeks before study enrollment 8. Female subjects who are currently pregnant, breastfeeding, or having a plan to get pregnant. If pregnancy is suspected, pregnancy test must be performed before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in facial skin surface lipid amount after the application of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid baseline, week 2,4, 6 and 8 Sebumeter(quantitative),Qualitative changes in facial lipid profilesafter the application of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid baseline, week 2,4, 6 and 8 Facial sebum analysis by gas chromatography-mass spectrometry (qualitative) | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects of moisturizer containing licochalcone A, decanediol, L-carnitine, and salicylic acid week 2,4,6 and 8 Side effects such as erythema, dryness, scaling, stinging, burning and pruritus will be measured by 4-point grading scores,Patients' satisfaction of moisturizer containing licochalcone A, decanediol, L-carnitine, and salicylic acid week8 Satisfaction is evaluated by overall VAS score | — |
Countries
Thailand
Contacts
Public ContactChanat Kumtornrut
Division of Dermatology, Faculty of Medicine, Chulalongkorn university
Outcome results
None listed