Patients undergoing general anesthesia with endotracheal intubation. Fentanyl, Hemodynamic Response, Tracheal Intubation
Conditions
Interventions
Patients were stratified according to age as follows: 20 to 35 (group 1), 36 to 50 (group 2), 51 to 65 (group 3) , 66 to 80 years (group 4) . The up and down doses of intravenous fentanyl for bluntin
Experimental Drug
Patients were stratified according to age as follows: 20 to 35, 36 to 50, 51 to 65, 66 to 80 years. The up and down doses of intravenous fentanyl for blunting the hemodynamic response to tracheal int
Sponsors
Neurological Institute of Thailand
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 20 - 80 years 2. Undergoing general anesthesia with ETT 3. Elective surgery 4. ASA physical status I or II 5. No history of fentanyl allergy
Exclusion criteria
Exclusion criteria: 1. In OR, at the time of induction ( BP greater than or equal to 180/110 mmHg) 2. Expected difficult airway 3. BMI greater than or equal to 30 kg/m2 4. Fentanyl was given within 4 hours of admission to the study 5. Ischemic heart disease, arrhythmia 6. Increased ICP 7. Creatinine clearance less than 30 ml/min
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Median Effective Dose (ED 50) and 95% Effective Dose (ED 95) of intravenous fentanyl for blunting the hemodynamic response to tracheal intubation at 1, 3, 5, 10 minutes after end of the intervention The Median Effective Dose (ED 50) and 95% Effective Dose (ED 95) | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of adverse events associated with the use of fentanyl at 1, 3, 5, 10 minutes after end of the intervention Patient reported outcome using a question. Clinical signs and hemodynamic changes were observed. | — |
Countries
Thailand
Contacts
Public ContactJatuporn Eiamcharoenwit
Department of Anesthesiology, Neurological Institute of Thailand
Outcome results
None listed