Delayed Chemotherapy Induce Nausea and Vomiting in Oxaliplatin Based Regimen Chemotherapy CINV
Conditions
Interventions
premedication before chemotherapy contain prochlorperazine 10 mg po bid combination with standard emetic regimen with dexamethasone 10 mg IV and ondansetron 8 mg IV
maintainance phase in day 2-4 post-
Experimental Drug,Placebo Comparator Drug
prochlorperazine,placebo
Sponsors
medical oncology unit, Faculty of medicine, Chulalongkorn university
Central Poly Trading Co., Ltd.
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. colorectal caner receiving 1st cycle of oxaliplatin based chemotherapy 2. not prior receive oxaliplatin 3. allow both palliative and curative intent 4. allow biologic agent such as antiVEGR antiEGFR
Exclusion criteria
Exclusion criteria: 1. history of bowel obstruction 2. nausea/vomiting symptom before receive chemotherapy 3. drug allergy of prochlorperazine, ondansetron, dexamethasone 4. abnormal liver or renal function 5. have psychotic problem 6. have history of seizure and dyskinesia 7. QT prolongation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| complete response in delayed phase within 5 day after intervention proportion | — |
Secondary
| Measure | Time frame |
|---|---|
| complete response in acute phase and overall phase within 5 days proportion,complete controlled in acute, delay and overall phase within 5 days proportion,nausea severity within 5 days visual analog scale ,adverse effect within 5 days patient report outcome,patients preference end of study proportion | — |
Countries
Thailand
Contacts
Public Contactpitan wongkongkathep
Faculty of medicine, Chulalongkorn university
Outcome results
None listed