healthy human volunteers Anesthesia, local, lidocaine, prilocaine, EMLA, depth, onset, duration
Conditions
Interventions
1. Subjects were in a sitting position and put there arms on the test table.
2. Cleaned the subject'
s forearm area by wiping it with a cotton swab moistened with ethyl alcohol and waiting for dry.
3. Divided the area where the subject'
s anesthetic was applied into two sides: the subject'
s right forehand and left forehand.
4. Took a clear plastic sheet that has been cut into 8 grids, 2x2 square centimeters. Then pasted it on both the left and right forehands of the subjects.
5. In eac
Experimental Drug,Active Comparator Drug
10% Lidocaine cream,5% Lidocaine/Prilocaine cream
Sponsors
Srinakharinwirot University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers aged 18-50 years 2. Agree to participate in a research project voluntarily. All project details will be provided and sign in writing the consent to join the project (Informed consent)
Exclusion criteria
Exclusion criteria: 1. History of anesthetic allergy to Lidocaine or Prilocaine. 2. Having any underlying disease that may be affected by pain, stress and anesthesia, such as cardiovascular disease, diabetes mellitus, etc. 3. G-6-PD deficiency 4. History of keloids on the skin around the forearms 5. Have an infection or there is inflammation of the skin around the forearms 6. Skin sensitivity to tape 7. Pregnancy or breast feeding 8. Bleeding tendency 9. Cognitive impairment, severe psychiatric or psychological problems 10. Have an infectious disease that can be transmitted through blood, such as HIV infection, hepatitis B virus, etc. 11. Chronic pain 12. Fear of needles
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| onset of anesthesia at application time of 15, 30, 45, 60, 90, 120 and 150 minutes Using 22G-needle connected to the digital depth gauge inserted into skin and asked the subject to rate the pain by Verbal pain scale (VPS) | — |
Secondary
| Measure | Time frame |
|---|---|
| depth of anesthesia at application time of 15, 30, 45, 60, 90, 120 and 150 minutes Using 22G-needle connected to the digital depth gauge inserted into skin and asked the subject to rate the pain by Verbal pain scale (VPS),duration of anesthesia 30, 60 and 90 minutes after removal Using 22G-needle connected to the digital depth gauge inserted into skin and asked the subject to rate the pain by Verbal pain scale (VPS) | — |
Countries
Thailand
Contacts
Public ContactNichchanun Junputipong
Skin Center of Srinakharinwirot University
Outcome results
None listed